Serum protein binding alterations of selected cephalosporin antibiotics by fatty acids and their derivatives

• Published in: Journal of pharmaceutical sciences Vol. 69; no. 3; p. 354
• Main Authors: Pitkin, D H, Actor, P, Weisbach, J A
• Format: Journal Article
• Language: English
• Published: United States 01.03.1980
• Subjects: Blood Proteins - metabolism; Cephalosporins - blood; Fatty Acids - pharmacology; Humans; In Vitro Techniques; Protein Binding - drug effects; Structure-Activity Relationship; Triglycerides - metabolism

Saturated fatty acids containing 10--14 carbon atoms were more potent inhibitors of serum protein binding than those containing shorter or longer carbon chains. Introduction of unsaturation into chains containing 16 or 18 carbons increased their inhibitory potency. Triglycerides and fatty acid ester...