Tristetraprolin recruits functional mRNA decay complexes to ARE sequences

• Published in: Journal of cellular biochemistry Vol. 100; no. 6; pp. 1477 - 1492
• Main Authors: Hau, Heidi H., Walsh, Richard J., Ogilvie, Rachel L., Williams, Darlisha A., Reilly, Cavan S., Bohjanen, Paul R.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 15.04.2007
• Subjects: 3' Untranslated Regions - genetics; 3' Untranslated Regions - metabolism; AU-rich elements; Blotting, Western; Cell-Free System - metabolism; Chromatography, Affinity; deadenylation; Electrophoresis, Polyacrylamide Gel; Electrophoretic Mobility Shift Assay; exosome; Granulocyte-Macrophage Colony-Stimulating Factor - genetics; HeLa Cells; Humans; Interleukin-2 - genetics; mRNA decay; mRNA degradation; PM-scl75; Protein Binding; RNA Stability; Transfection; tristetraprolin; Tristetraprolin - genetics; Tristetraprolin - metabolism; Tristetraprolin - physiology; Tumor Necrosis Factor-alpha - genetics; Xrn1

AU‐rich elements (AREs) in the 3′ untranslated region (UTR) of numerous mammalian transcripts function as instability elements that promote rapid mRNA degradation. Tristetraprolin (TTP) is an ARE‐binding protein that promotes rapid mRNA decay through mechanisms that are poorly understood. A 31 nucle...