A new approach for drug discovery from glycobiology and phage-displayed peptide library technology

• Published in: Biochimica et biophysica acta Vol. 1780; no. 3; pp. 497 - 503
• Main Authors: Taki, Takao, Ishikawa, Dai, Ogino, Koichi, Tanaka, Michinori, Oku, Naoto, Asai, Tomohiro, Popa, Iuliana, Portoukalian, Jacques
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2008
• Subjects: Amino Acid Sequence; Angiogenesis; Animals; Antibodies, Monoclonal - immunology; Cell Adhesion - drug effects; Drug Design; Drug discovery; G(M1) Ganglioside - analogs & derivatives; G(M1) Ganglioside - pharmacology; Ganglioside; Gangliosides - immunology; Glyco-replica peptide; Glycobiology; Glycolipid; Glycomics - methods; Glycosphingolipids - chemistry; Glycosphingolipids - metabolism; Humans; Melanoma; Melanoma - blood supply; Melanoma - immunology; Melanoma - pathology; Metastasis; Mice; Molecular mimicry; Molecular Sequence Data; Neoplasm Metastasis; Neovascularization, Pathologic; Peptide Library; Peptides - chemistry; Peptides - immunology; Peptides - pharmacology; Phage displayed peptide library; Angiogenesis; Phage displayed peptide library; Glycobiology; Ganglioside; Melanoma; Glyco-replica peptide; Molecular mimicry; Drug discovery; Metastasis; Glycolipid

Peptides which mimic functional activities of glycosphingolipids were prepared by a technology of phage-displayed peptide library using monoclonal antibodies against glycosphingolipids. These peptides were named glyco-replica peptides. Peptides prepared with anti-GD1α antibody by this technology wer...