Application of Digital Cognitive Biomarkers for Alzheimer's Disease: Identifying Cognitive Process Changes and Impending Cognitive Decline

• Published in: Journal of Prevention of Alzheimer's Disease, The Vol. 8; no. 2; pp. 123 - 126
• Main Authors: Bock, J.R, Hara, Junko, Fortier, D, Lee, M.D, Petersen, R.C, Shankle, W.R
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 2021
• Subjects: Geriatrics/Gerontology; Medicine; Medicine & Public Health; Neurology; Original Research; clinical trial; Wordlist memory test; digital cognitive biomarkers; preclinical Alzheimer's disease; Bayesian modeling; preclinical Alzheimer’s disease

AbstractBackgroundRecent Alzheimer's disease (AD) trials have faced significant challenges to enroll pre-symptomatic or early stage AD subjects with biomarker positivity, minimal or no cognitive impairment, and likelihood to decline cognitively during a short trial period. Our previous study sh...