Tissue-specific requirements for FGF8 during early inner ear development
Several members of the FGF gene family have been shown to intervene from various tissue sources to direct otic placode induction and otic vesicle formation. In this study we define the roles of FGF8, found in different expression domains during this process, in mice and chickens. By conditional inac...
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| Published in | Mechanisms of development Vol. 126; no. 10; pp. 873 - 881 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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Ireland
Elsevier Ireland Ltd
01.10.2009
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0925-4773 1872-6356 1872-6356 |
| DOI | 10.1016/j.mod.2009.07.004 |
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| Abstract | Several members of the FGF gene family have been shown to intervene from various tissue sources to direct otic placode induction and otic vesicle formation. In this study we define the roles of FGF8, found in different expression domains during this process, in mice and chickens. By conditional inactivation of
Fgf8 in distinct tissue compartments we demonstrate that
Fgf8 is required in the mesoderm and endoderm during early inner ear development. In the chicken embryo, overexpression of
Fgf8 from various tissue sources during otic specification leads to a loss of otic tissue. In contrast ectopic overexpression of
Fgf10, a major player during murine otic induction, does not influence otic vesicle formation in chicken embryos but results in the formation of ectopic structures with a non-otic character. This study underlines the crucial role of a defined
Fgf8 expression pattern controlling inner ear formation in vertebrates. |
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| AbstractList | Several members of the FGF gene family have been shown to intervene from various tissue sources to direct otic placode induction and otic vesicle formation. In this study we define the roles of FGF8, found in different expression domains during this process, in mice and chickens. By conditional inactivation of Fgf8 in distinct tissue compartments we demonstrate that Fgf8 is required in the mesoderm and endoderm during early inner ear development. In the chicken embryo, overexpression of Fgf8 from various tissue sources during otic specification leads to a loss of otic tissue. In contrast ectopic overexpression of Fgf10, a major player during murine otic induction, does not influence otic vesicle formation in chicken embryos but results in the formation of ectopic structures with a non-otic character. This study underlines the crucial role of a defined Fgf8 expression pattern controlling inner ear formation in vertebrates. Several members of the FGF gene family have been shown to intervene from various tissue sources to direct otic placode induction and otic vesicle formation. In this study we define the roles of FGF8, found in different expression domains during this process, in mice and chickens. By conditional inactivation of Fgf8 in distinct tissue compartments we demonstrate that Fgf8 is required in the mesoderm and endoderm during early inner ear development. In the chicken embryo, overexpression of Fgf8 from various tissue sources during otic specification leads to a loss of otic tissue. In contrast ectopic overexpression of Fgf10, a major player during murine otic induction, does not influence otic vesicle formation in chicken embryos but results in the formation of ectopic structures with a non-otic character. This study underlines the crucial role of a defined Fgf8 expression pattern controlling inner ear formation in vertebrates.Several members of the FGF gene family have been shown to intervene from various tissue sources to direct otic placode induction and otic vesicle formation. In this study we define the roles of FGF8, found in different expression domains during this process, in mice and chickens. By conditional inactivation of Fgf8 in distinct tissue compartments we demonstrate that Fgf8 is required in the mesoderm and endoderm during early inner ear development. In the chicken embryo, overexpression of Fgf8 from various tissue sources during otic specification leads to a loss of otic tissue. In contrast ectopic overexpression of Fgf10, a major player during murine otic induction, does not influence otic vesicle formation in chicken embryos but results in the formation of ectopic structures with a non-otic character. This study underlines the crucial role of a defined Fgf8 expression pattern controlling inner ear formation in vertebrates. Several members of the FGF gene family have been shown to intervene from various tissue sources to direct otic placode induction and otic vesicle formation. In this study we define the roles of FGF8, found in different expression domains during this process, in mice and chickens. By conditional inactivation of Fgf8 in distinct tissue compartments we demonstrate that Fgf8 is required in the mesoderm and endoderm during early inner ear development. In the chicken embryo, overexpression of Fgf8 from various tissue sources during otic specification leads to a loss of otic tissue. In contrast ectopic overexpression of Fgf10, a major player during murine otic induction, does not influence otic vesicle formation in chicken embryos but results in the formation of ectopic structures with a non-otic character. This study underlines the crucial role of a defined Fgf8 expression pattern controlling inner ear formation in vertebrates. |
| Author | Ros, Marian Schimmang, Thomas Alvarez, Yolanda López-Hernández, Iris Domínguez-Frutos, Elena Vendrell, Victor Zelarayan, Laura Cecilia |
| Author_xml | – sequence: 1 givenname: Elena surname: Domínguez-Frutos fullname: Domínguez-Frutos, Elena organization: Instituto de Biología y Genética Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Científicas, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), C/Sanz y Forés s/n, E-47003 Valladolid, Spain – sequence: 2 givenname: Victor surname: Vendrell fullname: Vendrell, Victor organization: Center for Molecular Neurobiology, University of Hamburg, Falkenried 94, D-20251 Hamburg, Germany – sequence: 3 givenname: Yolanda surname: Alvarez fullname: Alvarez, Yolanda organization: Center for Molecular Neurobiology, University of Hamburg, Falkenried 94, D-20251 Hamburg, Germany – sequence: 4 givenname: Laura Cecilia surname: Zelarayan fullname: Zelarayan, Laura Cecilia organization: Center for Molecular Neurobiology, University of Hamburg, Falkenried 94, D-20251 Hamburg, Germany – sequence: 5 givenname: Iris surname: López-Hernández fullname: López-Hernández, Iris organization: Instituto de Biología y Genética Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Científicas, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), C/Sanz y Forés s/n, E-47003 Valladolid, Spain – sequence: 6 givenname: Marian surname: Ros fullname: Ros, Marian organization: Instituto de Biomedicina y Biotecnología de Cantabria, IBBTEC (CSIC-UC-IDICAN) C/ Herera Oria s/n, E-39011 Santander, Spain – sequence: 7 givenname: Thomas surname: Schimmang fullname: Schimmang, Thomas email: schimman@ibgm.uva.es organization: Instituto de Biología y Genética Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Científicas, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), C/Sanz y Forés s/n, E-47003 Valladolid, Spain |
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| Keywords | Otic placode Fibroblast growth factor Chicken Otic vesicle Mouse |
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Dev. doi: 10.1016/S0925-4773(01)00550-0 |
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| Snippet | Several members of the FGF gene family have been shown to intervene from various tissue sources to direct otic placode induction and otic vesicle formation. In... |
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| SubjectTerms | Animals Chick Embryo Chicken Ear, Inner - embryology Ear, Inner - physiology Fibroblast growth factor Fibroblast Growth Factor 3 - genetics Fibroblast Growth Factor 3 - physiology Fibroblast Growth Factor 8 - genetics Fibroblast Growth Factor 8 - physiology Gene Expression Regulation, Developmental In Situ Hybridization Mice Mice, Transgenic Mouse Otic placode Otic vesicle |
| Title | Tissue-specific requirements for FGF8 during early inner ear development |
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