PDGF-D/PDGFRβ promotes tongue squamous carcinoma cell (TSCC) progression via activating p38/AKT/ERK/EMT signal pathway

• Published in: Biochemical and biophysical research communications Vol. 478; no. 2; pp. 845 - 851
• Main Authors: Zhang, Hong, Sun, Jia-Dong, Yan, Ling-jian, Zhao, Xiao-Peng
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 16.09.2016
• Subjects: Antigens, CD - genetics; Antigens, CD - metabolism; Cadherins - genetics; Cadherins - metabolism; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Cell Line, Tumor; Cell Movement; Disease Progression; Epithelial-Mesenchymal Transition - genetics; Gene Expression Regulation, Neoplastic; Humans; Lymphokines - antagonists & inhibitors; Lymphokines - genetics; Lymphokines - metabolism; Mitogen-Activated Protein Kinase 3 - genetics; Mitogen-Activated Protein Kinase 3 - metabolism; Neoplasm Invasiveness; p38 Mitogen-Activated Protein Kinases - genetics; p38 Mitogen-Activated Protein Kinases - metabolism; p38/AKT/ERK/EMT signal pathway; PDGF-D/PDGFRβ; Phosphorylation; Platelet-Derived Growth Factor - antagonists & inhibitors; Platelet-Derived Growth Factor - genetics; Platelet-Derived Growth Factor - metabolism; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; Receptor, Platelet-Derived Growth Factor beta - antagonists & inhibitors; Receptor, Platelet-Derived Growth Factor beta - genetics; Receptor, Platelet-Derived Growth Factor beta - metabolism; RNA, Small Interfering - genetics; RNA, Small Interfering - metabolism; Signal Transduction; Snail Family Transcription Factors - genetics; Snail Family Transcription Factors - metabolism; Tongue Neoplasms - genetics; Tongue Neoplasms - metabolism; Tongue Neoplasms - pathology; TSCC; Vimentin - genetics; Vimentin - metabolism; TSCC; PDGF-D/PDGFRβ; p38/AKT/ERK/EMT signal pathway

Platelet-derived growth factor D (PDGF-D) signaling plays significant roles during the development and progression of human malignancies via interacting with the receptor of PDGF-D (PDGFR). Meanwhile, the majority of human tumor metastasis is closely associated with epithelial-mesenchymal transition...