Folic Acid and Vitamin B12 Supplementation and the Risk of Cancer: Long-term Follow-up of the B Vitamins for the Prevention of Osteoporotic Fractures (B-PROOF) Trial

• Published in: Cancer epidemiology, biomarkers & prevention Vol. 28; no. 2; pp. 275 - 282
• Main Authors: Oliai Araghi, Sadaf, Kiefte-de Jong, Jessica C., van Dijk, Suzanne C., Swart, Karin M.A., van Laarhoven, Hanneke W., van Schoor, Natasja M., de Groot, Lisette C.P.G.M., Lemmens, Valery, Stricker, Bruno H., Uitterlinden, André G., van der Velde, Nathalie
• Format: Journal Article
• Language: English
• Published: United States 01.02.2019
• Subjects: Aged; Aged, 80 and over; Chair Nutrition and Health over the Lifecourse; Colorectal Neoplasms - chemically induced; Colorectal Neoplasms - epidemiology; Dietary Supplements; Double-Blind Method; Female; Folic Acid - adverse effects; Folic Acid - therapeutic use; Follow-Up Studies; Global Nutrition; HNE Nutrition and Health over the Lifecourse; HNE Voeding en Gezondheid in de Levenscyclus; Humans; Incidence; Male; Neoplasms - chemically induced; Neoplasms - epidemiology; Netherlands - epidemiology; Osteoporotic Fractures - prevention & control; Vitamin B 12 - adverse effects; Vitamin B 12 - therapeutic use; VLAG; Wereldvoeding; Netherlands

Folic acid and vitamin B12 play key roles in one-carbon metabolism. Disruption of one-carbon metabolism may be involved in the risk of cancer. Our aim was to assess the long-term effect of supplementation with both folic acid and vitamin B12 on the incidence of overall cancer and on colorectal cance...