Outcomes of Palliative Radiotherapy in Metastatic Epidural Spinal Cord Compression in Lung Cancer—A Prospective Observational Study from Tata Memorial Hospital
Abstract Background Metastatic epidural spinal cord compression (MESCC) secondary to lung cancer (LC) is a debilitating complication associated with poor prognosis and is commonly treated with radiotherapy (RT). There is no consensus for RT dose fractionation in spinal cord compression. Methods Fort...
Saved in:
| Published in | South Asian journal of cancer Vol. 10; no. 2; pp. 120 - 126 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
A-12, Second Floor, Sector -2, NOIDA -201301, India
Thieme Medical and Scientific Publishers Private Ltd
01.04.2021
Thieme Medical and Scientific Publishers Pvt. Ltd |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Abstract
Background
Metastatic epidural spinal cord compression (MESCC) secondary to lung cancer (LC) is a debilitating complication associated with poor prognosis and is commonly treated with radiotherapy (RT). There is no consensus for RT dose fractionation in spinal cord compression.
Methods
Forty consecutive patients of LC with radiological evidence of MESCC treated with palliative RT were evaluated for functional outcomes (pain, ambulation, and sphincter function) at 2-, 4-, and 24-week post RT completion. Pain assessment was done using visual analogue scale (VAS) and response was categorized according to international consensus criteria, ambulation status (AS) using Tomita’s scale, and sphincter function by the presence or absence of a catheter. Overall survival (OS) was assessed using Kaplan-Meier method and compared using log-rank test. Impact of potential prognostic factors on survival was also analyzed and
p
-value ≤0.05 was considered significant.
Results
Sixteen, 22, and two patients received 8 Gy single fraction (SF), 20 Gy in five fractions (20/5), and 30 Gy in 10 fractions (30/10), respectively. At 2 weeks, overall response (OR) rates of pain, ambulation, and sphincter control were 73, 81, and 81%, respectively. At 4 and 24 weeks, 93.7, 84.3, 87.5% and 88, 94, 76.5% had OR, respectively. Median OS was 4 months. Six- and 12-months OS was 50 and 37.5%. Nonsignificant difference in OS was seen between SF and 20/5 fractions (median 2.2 vs. 7.1 months,
p
= 0.39). Age ≤50 years was the only significant factor (
p
<0.05) in univariate analysis for OS.
Conclusion
Radiotherapy provided equivalent pain control, ambulation, and sphincter function compared with reported literature in MESCC. Nonsignificant difference in OS exists between SF and multifraction RT regimens. |
|---|---|
| AbstractList | Background Metastatic epidural spinal cord compression (MESCC) secondary to lung cancer (LC) is a debilitating complication associated with poor prognosis and is commonly treated with radiotherapy (RT). There is no consensus for RT dose fractionation in spinal cord compression. Methods Forty consecutive patients of LC with radiological evidence of MESCC treated with palliative RT were evaluated for functional outcomes (pain, ambulation, and sphincter function) at 2-, 4-, and 24-week post RT completion. Pain assessment was done using visual analogue scale (VAS) and response was categorized according to international consensus criteria, ambulation status (AS) using Tomita’s scale, and sphincter function by the presence or absence of a catheter. Overall survival (OS) was assessed using Kaplan-Meier method and compared using log-rank test. Impact of potential prognostic factors on survival was also analyzed and p-value ≤0.05 was considered significant. Results Sixteen, 22, and two patients received 8 Gy single fraction (SF), 20 Gy in five fractions (20/5), and 30 Gy in 10 fractions (30/10), respectively. At 2 weeks, overall response (OR) rates of pain, ambulation, and sphincter control were 73, 81, and 81%, respectively. At 4 and 24 weeks, 93.7, 84.3, 87.5% and 88, 94, 76.5% had OR, respectively. Median OS was 4 months. Six- and 12-months OS was 50 and 37.5%. Nonsignificant difference in OS was seen between SF and 20/5 fractions (median 2.2 vs. 7.1 months, p = 0.39). Age ≤50 years was the only significant factor (p <0.05) in univariate analysis for OS. Conclusion Radiotherapy provided equivalent pain control, ambulation, and sphincter function compared with reported literature in MESCC. Nonsignificant difference in OS exists between SF and multifraction RT regimens. Abstract Background Metastatic epidural spinal cord compression (MESCC) secondary to lung cancer (LC) is a debilitating complication associated with poor prognosis and is commonly treated with radiotherapy (RT). There is no consensus for RT dose fractionation in spinal cord compression. Methods Forty consecutive patients of LC with radiological evidence of MESCC treated with palliative RT were evaluated for functional outcomes (pain, ambulation, and sphincter function) at 2-, 4-, and 24-week post RT completion. Pain assessment was done using visual analogue scale (VAS) and response was categorized according to international consensus criteria, ambulation status (AS) using Tomita’s scale, and sphincter function by the presence or absence of a catheter. Overall survival (OS) was assessed using Kaplan-Meier method and compared using log-rank test. Impact of potential prognostic factors on survival was also analyzed and p -value ≤0.05 was considered significant. Results Sixteen, 22, and two patients received 8 Gy single fraction (SF), 20 Gy in five fractions (20/5), and 30 Gy in 10 fractions (30/10), respectively. At 2 weeks, overall response (OR) rates of pain, ambulation, and sphincter control were 73, 81, and 81%, respectively. At 4 and 24 weeks, 93.7, 84.3, 87.5% and 88, 94, 76.5% had OR, respectively. Median OS was 4 months. Six- and 12-months OS was 50 and 37.5%. Nonsignificant difference in OS was seen between SF and 20/5 fractions (median 2.2 vs. 7.1 months, p = 0.39). Age ≤50 years was the only significant factor ( p <0.05) in univariate analysis for OS. Conclusion Radiotherapy provided equivalent pain control, ambulation, and sphincter function compared with reported literature in MESCC. Nonsignificant difference in OS exists between SF and multifraction RT regimens. Background Metastatic epidural spinal cord compression (MESCC) secondary to lung cancer (LC) is a debilitating complication associated with poor prognosis and is commonly treated with radiotherapy (RT). There is no consensus for RT dose fractionation in spinal cord compression. Methods Forty consecutive patients of LC with radiological evidence of MESCC treated with palliative RT were evaluated for functional outcomes (pain, ambulation, and sphincter function) at 2-, 4-, and 24-week post RT completion. Pain assessment was done using visual analogue scale (VAS) and response was categorized according to international consensus criteria, ambulation status (AS) using Tomita’s scale, and sphincter function by the presence or absence of a catheter. Overall survival (OS) was assessed using Kaplan-Meier method and compared using log-rank test. Impact of potential prognostic factors on survival was also analyzed and p -value ≤0.05 was considered significant. Results Sixteen, 22, and two patients received 8 Gy single fraction (SF), 20 Gy in five fractions (20/5), and 30 Gy in 10 fractions (30/10), respectively. At 2 weeks, overall response (OR) rates of pain, ambulation, and sphincter control were 73, 81, and 81%, respectively. At 4 and 24 weeks, 93.7, 84.3, 87.5% and 88, 94, 76.5% had OR, respectively. Median OS was 4 months. Six- and 12-months OS was 50 and 37.5%. Nonsignificant difference in OS was seen between SF and 20/5 fractions (median 2.2 vs. 7.1 months, p = 0.39). Age ≤50 years was the only significant factor ( p <0.05) in univariate analysis for OS. Conclusion Radiotherapy provided equivalent pain control, ambulation, and sphincter function compared with reported literature in MESCC. Nonsignificant difference in OS exists between SF and multifraction RT regimens. Background Metastatic epidural spinal cord compression (MESCC) secondary to lung cancer (LC) is a debilitating complication associated with poor prognosis and is commonly treated with radiotherapy (RT). There is no consensus for RT dose fractionation in spinal cord compression. Methods Forty consecutive patients of LC with radiological evidence of MESCC treated with palliative RT were evaluated for functional outcomes (pain, ambulation, and sphincter function) at 2-, 4-, and 24-week post RT completion. Pain assessment was done using visual analogue scale (VAS) and response was categorized according to international consensus criteria, ambulation status (AS) using Tomita’s scale, and sphincter function by the presence or absence of a catheter. Overall survival (OS) was assessed using Kaplan-Meier method and compared using log-rank test. Impact of potential prognostic factors on survival was also analyzed and p-value ≤0.05 was considered significant. Results Sixteen, 22, and two patients received 8 Gy single fraction (SF), 20 Gy in five fractions (20/5), and 30 Gy in 10 fractions (30/10), respectively. At 2 weeks, overall response (OR) rates of pain, ambulation, and sphincter control were 73, 81, and 81%, respectively. At 4 and 24 weeks, 93.7, 84.3, 87.5% and 88, 94, 76.5% had OR, respectively. Median OS was 4 months. Six- and 12-months OS was 50 and 37.5%. Nonsignificant difference in OS was seen between SF and 20/5 fractions (median 2.2 vs. 7.1 months, p = 0.39). Age ≤50 years was the only significant factor (p <0.05) in univariate analysis for OS. Conclusion Radiotherapy provided equivalent pain control, ambulation, and sphincter function compared with reported literature in MESCC. Nonsignificant difference in OS exists between SF and multifraction RT regimens. Background Metastatic epidural spinal cord compression (MESCC) secondary to lung cancer (LC) is a debilitating complication associated with poor prognosis and is commonly treated with radiotherapy (RT). There is no consensus for RT dose fractionation in spinal cord compression. Methods Forty consecutive patients of LC with radiological evidence of MESCC treated with palliative RT were evaluated for functional outcomes (pain, ambulation, and sphincter function) at 2-, 4-, and 24-week post RT completion. Pain assessment was done using visual analogue scale (VAS) and response was categorized according to international consensus criteria, ambulation status (AS) using Tomita's scale, and sphincter function by the presence or absence of a catheter. Overall survival (OS) was assessed using Kaplan-Meier method and compared using log-rank test. Impact of potential prognostic factors on survival was also analyzed and p -value ≤0.05 was considered significant. Results Sixteen, 22, and two patients received 8 Gy single fraction (SF), 20 Gy in five fractions (20/5), and 30 Gy in 10 fractions (30/10), respectively. At 2 weeks, overall response (OR) rates of pain, ambulation, and sphincter control were 73, 81, and 81%, respectively. At 4 and 24 weeks, 93.7, 84.3, 87.5% and 88, 94, 76.5% had OR, respectively. Median OS was 4 months. Six- and 12-months OS was 50 and 37.5%. Nonsignificant difference in OS was seen between SF and 20/5 fractions (median 2.2 vs. 7.1 months, p = 0.39). Age ≤50 years was the only significant factor ( p <0.05) in univariate analysis for OS. Conclusion Radiotherapy provided equivalent pain control, ambulation, and sphincter function compared with reported literature in MESCC. Nonsignificant difference in OS exists between SF and multifraction RT regimens.Background Metastatic epidural spinal cord compression (MESCC) secondary to lung cancer (LC) is a debilitating complication associated with poor prognosis and is commonly treated with radiotherapy (RT). There is no consensus for RT dose fractionation in spinal cord compression. Methods Forty consecutive patients of LC with radiological evidence of MESCC treated with palliative RT were evaluated for functional outcomes (pain, ambulation, and sphincter function) at 2-, 4-, and 24-week post RT completion. Pain assessment was done using visual analogue scale (VAS) and response was categorized according to international consensus criteria, ambulation status (AS) using Tomita's scale, and sphincter function by the presence or absence of a catheter. Overall survival (OS) was assessed using Kaplan-Meier method and compared using log-rank test. Impact of potential prognostic factors on survival was also analyzed and p -value ≤0.05 was considered significant. Results Sixteen, 22, and two patients received 8 Gy single fraction (SF), 20 Gy in five fractions (20/5), and 30 Gy in 10 fractions (30/10), respectively. At 2 weeks, overall response (OR) rates of pain, ambulation, and sphincter control were 73, 81, and 81%, respectively. At 4 and 24 weeks, 93.7, 84.3, 87.5% and 88, 94, 76.5% had OR, respectively. Median OS was 4 months. Six- and 12-months OS was 50 and 37.5%. Nonsignificant difference in OS was seen between SF and 20/5 fractions (median 2.2 vs. 7.1 months, p = 0.39). Age ≤50 years was the only significant factor ( p <0.05) in univariate analysis for OS. Conclusion Radiotherapy provided equivalent pain control, ambulation, and sphincter function compared with reported literature in MESCC. Nonsignificant difference in OS exists between SF and multifraction RT regimens. |
| Author | Mummudi, Naveen Sharma, Alisha Agarwal, Jaiprakash Tibdewal, Anil Gurram, Lavanya |
| AuthorAffiliation | 1 Department of Radiation Oncology, Homi Bhabha National Institute, Tata Memorial Centre, Mumbai, Maharashtra, India |
| AuthorAffiliation_xml | – name: 1 Department of Radiation Oncology, Homi Bhabha National Institute, Tata Memorial Centre, Mumbai, Maharashtra, India |
| Author_xml | – sequence: 1 givenname: Anil surname: Tibdewal fullname: Tibdewal, Anil organization: Department of Radiation Oncology, Homi Bhabha National Institute, Tata Memorial Centre, Mumbai, Maharashtra, India – sequence: 2 givenname: Alisha surname: Sharma fullname: Sharma, Alisha organization: Department of Radiation Oncology, Homi Bhabha National Institute, Tata Memorial Centre, Mumbai, Maharashtra, India – sequence: 3 givenname: Lavanya surname: Gurram fullname: Gurram, Lavanya organization: Department of Radiation Oncology, Homi Bhabha National Institute, Tata Memorial Centre, Mumbai, Maharashtra, India – sequence: 4 givenname: Naveen surname: Mummudi fullname: Mummudi, Naveen organization: Department of Radiation Oncology, Homi Bhabha National Institute, Tata Memorial Centre, Mumbai, Maharashtra, India – sequence: 5 givenname: Jaiprakash surname: Agarwal fullname: Agarwal, Jaiprakash email: agarwaljp@tmc.gov.in organization: Department of Radiation Oncology, Tata Memorial Centre |
| BookMark | eNp1ks9qGzEQxpeS0qRprj3r2Msm-rOr1V4KwSRNwMWhSaE3IUuztsyutJW0Bt_6EH2BvlqepHJsCjn0ohEz3_cbNJr3xYnzDoriI8GXBNf1VSwxrkhJGkZazN4UZ5Q2oqwY5ifHO2P4x2lxEeMGY0wwY6Il74pTVtVcUMrPij-LKWk_QES-Qw-q761KdgvomzLWpzUENe6QdegrJBVTrml0M1ozBdWjx9G6HGY-mHwMY4AYrXd7-XxyKzRTTkN4_vX7Gj0EH0fQL-jFMkLYZpTfux_TZHaoC35ATyqp3GjwwebCXXbYpPoPxdtO9REujvG8-H578zS7K-eLL_ez63mpK8pTCRyYMrxbcjAtNqwzIme40DXhSyo0po2pFbCqaUnbmVZ0zZJpjBuGQRGo2Xlxf-AarzZyDHZQYSe9svIl4cNKqpDf34OkomG1MEC0VlWHteA6N8eqabShtG4z6_OBNU7LAYwGl_LAXkFfV5xdy5XfSlFxzKoqAz4dAcH_nCAmOdiooe-VAz9FSeuGt7gVQmTp5UGq84xjgO5fG4Llfk1klPs1kcc1yYbyYEhrCwPIjZ9C_on4P_1fYa3DPg |
| Cites_doi | 10.1016/S0140-6736(05)66954-1 10.1200/JCO.2005.05.0542 10.1001/jama.2019.17913 10.1002/cncr.25223 10.1056/NEJMoa1408440 10.1016/j.ijrobp.2012.01.014 10.3109/02841868309134353 10.1056/NEJM199208273270907 10.1056/NEJMoa0810699 10.1016/j.ijrobp.2011.02.008 10.1007/s00066-011-2266-y 10.1016/j.radonc.2009.05.012 10.1200/JCO.2015.64.0862 10.1016/j.radonc.2019.01.019 10.1215/S1152851704000262 10.1186/1471-2407-12-302 10.1080/0284186X.2018.1433320 10.1016/j.spinee.2015.02.015 10.1200/JCO.2005.08.193 10.1016/j.ijrobp.2014.10.036 |
| ContentType | Journal Article |
| Copyright | MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/). MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/). 2021 MedIntel Services Pvt Ltd |
| Copyright_xml | – notice: MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/). – notice: MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/). 2021 MedIntel Services Pvt Ltd |
| DBID | 0U6 AAYXX CITATION 7X8 5PM DOA |
| DOI | 10.1055/s-0041-1731903 |
| DatabaseName | Thieme Connect Journals Open Access CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE - Academic |
| DatabaseTitleList | CrossRef MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: 0U6 name: Thieme Connect Journals Open Access url: http://open.thieme.com sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2278-4306 |
| EndPage | 126 |
| ExternalDocumentID | oai_doaj_org_article_287358de1cca4f0c86ce3a0a77cd2259 PMC8460344 10_1055_s_0041_1731903 |
| GroupedDBID | 0R~ 0U6 5VS ABXLX ACGFS ADBBV ADRAZ AHRAW ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV DIK EBS EMOBN GROUPED_DOAJ H13 HYE IAO IHR IPNFZ ITC KQ8 M48 OK1 PGMZT RIG RMW RPM RTC W3E AAYXX CITATION 7X8 M~E 5PM |
| ID | FETCH-LOGICAL-c426t-e6e3ad6fb6ed90d3fd86e368c516b28c027d5ae347919fd98f7b3c00730ea1e53 |
| IEDL.DBID | M48 |
| ISSN | 2278-330X |
| IngestDate | Wed Aug 27 00:23:28 EDT 2025 Thu Aug 21 18:12:35 EDT 2025 Fri Jul 11 08:08:35 EDT 2025 Tue Jul 01 01:39:15 EDT 2025 Sun Nov 24 15:08:15 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | lung cancer radiotherapy cord compression ambulation |
| Language | English |
| License | CC BY-NC-ND 4.0 https://creativecommons.org/licenses/by-nc-nd/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c426t-e6e3ad6fb6ed90d3fd86e368c516b28c027d5ae347919fd98f7b3c00730ea1e53 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1055/s-0041-1731903 |
| PMID | 34568226 |
| PQID | 2576909888 |
| PQPubID | 23479 |
| PageCount | 7 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_287358de1cca4f0c86ce3a0a77cd2259 pubmedcentral_primary_oai_pubmedcentral_nih_gov_8460344 proquest_miscellaneous_2576909888 crossref_primary_10_1055_s_0041_1731903 thieme_journals_10_1055_s_0041_1731903 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2021-04-01 |
| PublicationDateYYYYMMDD | 2021-04-01 |
| PublicationDate_xml | – month: 04 year: 2021 text: 2021-04-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | A-12, Second Floor, Sector -2, NOIDA -201301, India |
| PublicationPlace_xml | – name: A-12, Second Floor, Sector -2, NOIDA -201301, India |
| PublicationTitle | South Asian journal of cancer |
| PublicationTitleAlternate | South Asian J Cancer |
| PublicationYear | 2021 |
| Publisher | Thieme Medical and Scientific Publishers Private Ltd Thieme Medical and Scientific Publishers Pvt. Ltd |
| Publisher_xml | – name: Thieme Medical and Scientific Publishers Private Ltd – name: Thieme Medical and Scientific Publishers Pvt. Ltd |
| References | P Thirion (ref10) 2014; 90 D Rades (ref18) 2006; 24 T S Mok (ref17) 2009; 361 S Ryu (ref4) 2015; 3 D Rades (ref9) 2016; 34 E Chow (ref13) 2012; 82 G T Silva (ref21) 2015; 15 E Maranzano (ref7) 2005; 23 R A Patchell (ref5) 2005; 366 E Maranzano (ref8) 2009; 93 T Tomita (ref14) 1983; 22 D Rades (ref20) 2012; 12 D Rades (ref3) 2010; 116 D Rades (ref19) 2011; 187 E K Donovan (ref15) 2019; 134 T N Byrne (ref2) 1992; 327 B J Solomon (ref16) 2014; 371 D A Loblaw (ref1) 2012; 84 P Klimo Jr (ref6) 2005; 7 P J Hoskin (ref12) 2019; 322 K A Lee (ref11) 2018; 57 |
| References_xml | – volume: 366 start-page: 643 year: 2005 ident: ref5 article-title: Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial publication-title: Lancet doi: 10.1016/S0140-6736(05)66954-1 – volume: 24 start-page: 3388 issue: 21 year: 2006 ident: ref18 article-title: Prognostic factors for local control and survival after radiotherapy of metastatic spinal cord compression publication-title: J Clin Oncol doi: 10.1200/JCO.2005.05.0542 – volume: 322 start-page: 2084 issue: 21 year: 2019 ident: ref12 article-title: Effect of single-fraction vs multifraction radiotherapy on ambulatory status among patients with spinal canal compression from metastatic cancer: the SCORAD randomized clinical trial publication-title: JAMA doi: 10.1001/jama.2019.17913 – volume: 116 start-page: 3670 issue: 15 year: 2010 ident: ref3 article-title: Validation and simplification of a score predicting survival in patients irradiated for metastatic spinal cord compression publication-title: Cancer doi: 10.1002/cncr.25223 – volume: 371 start-page: 2167 issue: 23 year: 2014 ident: ref16 article-title: First-line crizotinib versus chemotherapy in ALK-positive lung cancer publication-title: N Engl J Med doi: 10.1056/NEJMoa1408440 – volume: 84 start-page: 312 issue: 02 year: 2012 ident: ref1 article-title: A 2011 updated systematic review and clinical practice guideline for the management of malignant extradural spinal cord compression publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2012.01.014 – volume: 22 start-page: 135 issue: 02 year: 1983 ident: ref14 article-title: Radiation therapy for spinal epidural metastases with complete block publication-title: Acta Radiol Oncol doi: 10.3109/02841868309134353 – volume: 327 start-page: 614 issue: 09 year: 1992 ident: ref2 article-title: Spinal cord compression from epidural metastases publication-title: N Engl J Med doi: 10.1056/NEJM199208273270907 – volume: 361 start-page: 947 issue: 10 year: 2009 ident: ref17 article-title: Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma publication-title: N Engl J Med doi: 10.1056/NEJMoa0810699 – volume: 82 start-page: 1730 issue: 05 year: 2012 ident: ref13 article-title: International Bone Metastases Consensus Working Party. Update of the international consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2011.02.008 – volume: 187 start-page: 729 issue: 11 year: 2011 ident: ref19 article-title: Dose escalation of radiotherapy for metastatic spinal cord compression (MSCC) in patients with relatively favorable survival prognosis publication-title: Strahlenther Onkol doi: 10.1007/s00066-011-2266-y – volume: 93 start-page: 174 issue: 02 year: 2009 ident: ref8 article-title: 8Gy single-dose radiotherapy is effective in metastatic spinal cord compression: results of a phase III randomized multicentre Italian trial publication-title: Radiother Oncol doi: 10.1016/j.radonc.2009.05.012 – volume: 34 start-page: 597 issue: 06 year: 2016 ident: ref9 article-title: Radiotherapy with 4 Gy × 5 versus 3 Gy × 10 for metastatic epidural spinal cord compression: final results of the SCORE-2 Trial (ARO 2009/01) publication-title: J Clin Oncol doi: 10.1200/JCO.2015.64.0862 – volume: 134 start-page: 55 year: 2019 ident: ref15 article-title: Single versus multifraction radiotherapy for spinal cord compression: a systematic review and meta-analysis publication-title: Radiother Oncol doi: 10.1016/j.radonc.2019.01.019 – volume: 7 start-page: 64 issue: 01 year: 2005 ident: ref6 article-title: A meta-analysis of surgery versus conventional radiotherapy for the treatment of metastatic spinal epidural disease publication-title: Neuro-oncol doi: 10.1215/S1152851704000262 – volume: 3 start-page: 237 issue: 03 year: 2015 ident: ref4 article-title: International survey of the treatment of metastatic spinal cord compression publication-title: J Radiosurg SBRT – volume: 12 start-page: 302 year: 2012 ident: ref20 article-title: A validated survival score for patients with metastatic spinal cord compression from non-small cell lung cancer publication-title: BMC Cancer doi: 10.1186/1471-2407-12-302 – volume: 57 start-page: 965 issue: 07 year: 2018 ident: ref11 article-title: (ICORG 05-03): prospective randomized non-inferiority phase III trial comparing two radiation schedules in malignant spinal cord compression (not proceeding with surgical decompression); the quality of life analysis publication-title: Acta Oncol doi: 10.1080/0284186X.2018.1433320 – volume: 15 start-page: 1263 issue: 06 year: 2015 ident: ref21 article-title: Incidence, associated factors, and survival in metastatic spinal cord compression secondary to lung cancer publication-title: Spine J doi: 10.1016/j.spinee.2015.02.015 – volume: 23 start-page: 3358 issue: 15 year: 2005 ident: ref7 article-title: Short-course versus split-course radiotherapy in metastatic spinal cord compression: results of a phase III, randomized, multicenter trial publication-title: J Clin Oncol doi: 10.1200/JCO.2005.08.193 – volume: 90 start-page: 1263 issue: 05 year: 2014 ident: ref10 article-title: ICORG 05–03: prospective randomized non-inferiority phase 3 trial comparing two radiation schedules in malignant spinal cord compression not proceeding with surgical decompression publication-title: Int J Radiat Oncol doi: 10.1016/j.ijrobp.2014.10.036 |
| SSID | ssj0001033891 ssib050738867 |
| Score | 2.158288 |
| Snippet | Abstract
Background
Metastatic epidural spinal cord compression (MESCC) secondary to lung cancer (LC) is a debilitating complication associated with poor... Background Metastatic epidural spinal cord compression (MESCC) secondary to lung cancer (LC) is a debilitating complication associated with poor prognosis and... Background Metastatic epidural spinal cord compression (MESCC) secondary to lung cancer (LC) is a debilitating complication associated with poor prognosis and... |
| SourceID | doaj pubmedcentral proquest crossref thieme |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 120 |
| SubjectTerms | ambulation cord compression lung cancer Original : Lung Cancer Original Article: Lung Cancer radiotherapy |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NbtQwELZQhRAXxK_Y8iMjIThFTdax4xzLqlWFWFpBK-3N8s9EzaHJapM9cOMheAFejSdhJnGqXSTEhWsSxbHni2fGM_MNY28tWAdalsncBXRQXC6T0klKciQeSvQoxojp8rM6u8o_ruRqp9UX5YSN9MDjwh2hRS-kDpDhUHmVeq08CJvaovABsTiU7qHO23GmEElo5Aito2IdTltSIcb2eVT6maATv5oYHKU86hKinUqyAvE4dc-KGmog8t-zPv_MnbzbX9dwAzta6fQhexDNSX48TuMRuwPNY3ZvGQPmT9jP822PmIKOtxW_sHS2Qvsb_2JDHWuvvvG64UvoLdUW1Z6frOtAXBz865o6ZvEFuqecto0xY7ahxz_hFsEXBJjNr-8_jvnFpp1KNvm5uz3opZcQfS2nIhZ-aXuLA920hHk-NSx5yq5OTy4XZ0nsypB41OZ9AgrXP6jKKQhlGkQVNF5R2stMubn26OcGaYEqVLOyCqWuCic8RQRTsBlI8YwdNG0DzxkXlbMuB49eksiFq7Qv89wJp5QurMz0jL2fJGHWI_mGGYLmUprOkMxMlNmMfSBB3T5FpNnDBYSSiVAy_4LSjL2ZxGzwJ6PIiW2g3XaGvLIyLbXGTyr25L834v6dpr4e6LrRwiNexRl7NyLFxF2i-8tcDv_HXF6w-3PKvhlyjF6yg36zhVdoPvXu9fCn_AYFlBhh priority: 102 providerName: Directory of Open Access Journals – databaseName: Thieme Connect Journals Open Access dbid: 0U6 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwELZQQYgL4imWAjISglNEso4T-1hWrSrE0gq60t4sPyZqDk1Wm-yBGz-if4C_xi9hJo-FFCFxdSw71ozn4Zn5hrE3FqwDJXU0dwEdFJfKSDtJSY6EQ4keRR8xXX7OTlfpx7Vc_37vuBnBl_J9ExEmVJTkyCwE63l7HueaehXEq70iRaNGKDUo0u51JRaib5dHpZ4ROu3rEbHxryUnGqkD7p9YmzdzJe-0lyVcwR9a6OQBuz-Yj_yop_dDdguqR-zucgiQP2Y_znYt8hA0vC74uaW3FJJn_IsN5VBr9Y2XFV9Ca6mWqPT8eFMGwt7gXzfUIYsv0B3lJCb6DNmKpn9CkcAXxCDbn9-vj_j5th5LNPmZ2z_s0iIEV8upaIVf2NbiRlc18TgfG5Q8YauT44vFaTR0YYg8au82ggyEDVnhMgg6DqIICkcy5WWSubny6NcGaYEqUhNdBK2K3AlPEcAYbAJSPGUHVV3BM8ZF4axLwaNXJFLhCuV1mjrhskzlViZqxt6NlDCbHmzDdEFyKU1jiGZmoNmMfSBC7WcRSHY3gJxjhjtn0BkUUgVIkEvTIvYq83iU2Oa5DyjG9Iy9Hsls8FJRpMRWUO8aQ16YjrVS-Ev5hP6THadfqvKyg-dGi45wFGfsbc8pZpAKzT_O8vx_Jx6ye3PKqOnyhl6wg3a7g5doErXuVXcbfgGDuAYP priority: 102 providerName: Thieme |
| Title | Outcomes of Palliative Radiotherapy in Metastatic Epidural Spinal Cord Compression in Lung Cancer—A Prospective Observational Study from Tata Memorial Hospital |
| URI | http://dx.doi.org/10.1055/s-0041-1731903 https://www.proquest.com/docview/2576909888 https://pubmed.ncbi.nlm.nih.gov/PMC8460344 https://doaj.org/article/287358de1cca4f0c86ce3a0a77cd2259 |
| Volume | 10 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF5BQVUviKcIj2iREJwMdta7Xh9QVaJUFSK0gkbKbbUvU0vUDrYj0QviR_AH-Gv9Jcz40RIeFy45OJY3zszszLcz8w0hT7XXxkueBhPjAKCYmAep4VjkiDyUgCi6jOn8nThYxG-WfHlZ_9T_gfVfoR3Ok1pUn158-Xy2Cwb_qptSy1_WAbJGBVEC6oTEn9fAKyU4zWB-GepD2MOk7F1te_4SMtYN1MNm0ABg_XLgdPzjkTtkm0GgAb5UbLivluV_IzT9vbDyenOS-1P_i8vav0lu9LEm3euU4xa54ovbZHveZ9PvkB-H6wYUzte0zOiRxoMX3Pzoe-3yvjHrjOYFnftGY-NRbulslTsk6qAfVjhOi04Bu1LcU7py2gJvfwv7B52iNlXn377v0aOqHPo56aG5OAXGhyC3LcUOF3qsGw0LnZZoEHSYZnKXLPZnx9ODoB_ZEFhw9U3ghWfaicwI79LQscxJuCKk5ZEwE2kBBDuuPbavRmnmUpklhllMF4ZeR56ze2SrKAt_n1CWGW1ibwFCsZiZTNo0jg0zQshE80iOyPNBEmrVMXOoNqPOuaoVik_14huR1yioi7uQUbu9UFYfVW-gCpAj49L5CFQ6zkIrhYVXCXWSWAd7XjoiTwYxK7BATKvowpfrWiFkS8NUSvhJyYb8N1bc_KbIT1oubwj_kHRxRJ51mqIGC_jHuzz47yUekp0J1uO0VUePyFZTrf1jCKgaMyZXw4UYt8cR49Zq8PPr7CfCLCIV |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF5VBQEXxFOE5yLxOFm1s157feBQQquUJm0FiZTbdl8mlogdxY5Qb_wI_gD_g1_DL2HGj4iAkLj06qzs7M57Z-YbQl4op7QTPPH62kKAokPuJZpjkSPiUEJE0WRMxyfRcBq-n_HZDvnR9cJgWWU1z9zCeQYrPUyFpRbLBv203HPtCZd782rxuZ1Ty_dKD3GjvCAGhvK7UdbH7uILBHDlm6N3QO2X_f7hwWQw9NoZA54B21R5LnJM2SjVkbOJb1lqBTyJhOFBpPvCQNRmuXLYbxkkqU1EGmtmML_lOxU4nBkBBuAKDyFOAmnypxvjDo4WE6I17vWNj89YM8IP2089xvxZhyL51xa2rGQ9TGDLA_6zfvNqc2S_WcbDW-Rm69LS_YYHb5Mdl98h18Zt0v4u-X66roCvXUmLlJ4pvN9BHUs_KJu1_V8XNMvp2FUK-5syQw-WmUU8EPpxiVO76ABOmKLqaqp2c1w-AjVFB8i0q59fv-3Ts1XRtY3SU725bMaXIIQuxUYaOlGVgg8tCpQ72g1NuUeml0K1-2Q3L3L3gFCWaqVDZyBSYyHTqTBJGGqmo0jEigeiR153lJDLBgBE1ol7zmUpkWaypVmPvEVCbVYhcHf9oFh9kq0ekBCgMi6sC0BywtQ3IjKwFV_FsbGgWpMeed6RWYKgY_ZG5a5YlxIjw8RPhIC_FG_Rf-uL27_k2byGDAcvE7Ede-RVwymyk6N_7OXh_y58Rq4PJ-ORHB2dHD8iN_pY8VPXNT0mu9Vq7Z6Ay1bpp7VkUHJ-2aL4CwoCUjQ |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF5VBVVcEE8RnovE42TF9nrt9YFDSRu1tGkjaKTcln259aF2FDtCvfEj-AP8Ev4Lv4QZPyICQuLSq7OyszvvnZlvCHmlnNJO8NQLtYUARUfcSzXHIkfEoYSIos2YTk7ig1n0Yc7nW-RH3wuDZZX1Re4unWew0sPUWGqxaNFPq6HrTrgaLmzWjanlw8pD2CgvSICffIgNbdZVWR65qy8Qw1XvDveA4K_DcLx_NjrwujEDngHzVHsudkzZONOxs6lvWWYFPImF4UGsQ2EgcLNcOWy5DNLMpiJLNDOY4vKdChyOjQAbcIMjWBYIlD9b23fwtZgQnX1vLn18xtopftiB6jHmz3sgyb-2sWEom3kCG07wnyWcN9tT-804ju-Q251XS3dbNrxLtlxxj-xMurz9ffL9dFUDa7uKlhmdKrziQTVLPyqbdy1gVzQv6MTVClucckP3F7lFSBD6aYGDu-gITpii9moLdwtcfgyaio6Qb5c_v37bpdNl2XeO0lO9vm_GlyCKLsVeGnqmagUfuixR9Gg_N-UBmV0L1R6S7aIs3CNCWaaVjpyBYI1FTGfCpFGkmY5jkSgeiAF521NCLloMENnk7jmXlUSayY5mA_IeCbVehdjdzYNyeS47VSAhRmVcWBeA8ESZb0RsYCu-ShJjQbumA_KyJ7MEWccEjipcuaokBoepnwoBfynZoP_GFzd_KfKLBjUcHE2EdxyQNy2nyF6U_rGXx_-78AXZme6N5fHhydETcivEmp-msukp2a6XK_cMnLZaP28Eg5LP1y2JvwDM7lLH |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Outcomes+of+Palliative+Radiotherapy+in+Metastatic+Epidural+Spinal+Cord+Compression+in+Lung+Cancer%E2%80%94A+Prospective+Observational+Study+from+Tata+Memorial+Hospital&rft.jtitle=South+Asian+journal+of+cancer&rft.au=Tibdewal%2C+Anil&rft.au=Sharma%2C+Alisha&rft.au=Gurram%2C+Lavanya&rft.au=Mummudi%2C+Naveen&rft.date=2021-04-01&rft.pub=Thieme+Medical+and+Scientific+Publishers+Private+Ltd&rft.issn=2278-330X&rft.eissn=2278-4306&rft.volume=10&rft.issue=2&rft.spage=120&rft.epage=126&rft_id=info:doi/10.1055%2Fs-0041-1731903&rft_id=info%3Apmid%2F34568226&rft.externalDocID=PMC8460344 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2278-330X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2278-330X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2278-330X&client=summon |