CBX8 antagonizes the effect of Sirtinol on premature senescence through the AKT-RB-E2F1 pathway in K562 leukemia cells

• Published in: Biochemical and biophysical research communications Vol. 469; no. 4; pp. 884 - 890
• Main Authors: Lee, Sang Hyup, Um, Soo-Jong, Kim, Eun-Joo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 22.01.2016
• Subjects: Antineoplastic Agents - administration & dosage; Benzamides - administration & dosage; CBX8; Cell Cycle Checkpoints - drug effects; Cellular Senescence - drug effects; Drug Antagonism; E2F1 Transcription Factor - metabolism; Humans; K562 Cells; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology; Naphthols - administration & dosage; Oncogene Protein v-akt - metabolism; Polycomb Repressive Complex 1 - metabolism; Premature senescence; RB-E2F1; Retinoblastoma Protein - metabolism; Signal Transduction - drug effects; SIRT1; CBX8; RB; GFP; Premature senescence; Leukemia; RB-E2F1; SIRT1; β-gal

Although tyrosine kinase inhibitor (TKI) therapies are highly effective in the treatment of chronic myeloid leukemia (CML), frequent recurrence limits their usage and demands new approaches for CML therapy. Stress-induced premature senescence (SIPS) is considered a potential anticancer treatment, bu...