Crucial role of vHNF1 in vertebrate hepatic specification

• Published in: Development (Cambridge) Vol. 135; no. 16; pp. 2777 - 2786
• Main Authors: Lokmane, Ludmilla, Haumaitre, Cécile, Garcia-Villalba, Pilar, Anselme, Isabelle, Schneider-Maunoury, Sylvie, Cereghini, Silvia
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Limited 15.08.2008
• Subjects: Animals; Cell Differentiation - physiology; Endoderm - embryology; Endoderm - physiology; Female; Fibroblast Growth Factors - physiology; Hepatocyte Nuclear Factor 1-beta - genetics; Hepatocyte Nuclear Factor 1-beta - physiology; Hepatocytes - cytology; Hepatocytes - physiology; Liver - cytology; Liver - embryology; Liver - physiology; Male; Mesoderm - embryology; Mesoderm - physiology; Mice; Species Specificity; Zebrafish; Zebrafish Proteins - genetics; Zebrafish Proteins - physiology

Mouse liver induction occurs via the acquisition of ventral endoderm competence to respond to inductive signals from adjacent mesoderm, followed by hepatic specification. Little is known about the regulatory circuit involved in these processes. Through the analysis of vHnf1 ( Hnf1b )-deficient embry...