Non-linear oral bioavailability and clinical pharmacokinetics of high-dose Andrographis paniculata ethanolic extract: relevant dosage implications for COVID-19 treatment - Songvut, Phanit; Akanimanee, Jaratluck; Suriyo, Tawit; Pholphana, Nanthanit; Rangkadilok, Nuchanart; Panomvana, Duangchit; Puranajoti, Porranee; Satayavivad, Jutamaad (Pharmaceutical biology, 2025)
Keywords: Administration, Oral; Adult; Andrographis - chemistry; Andrographis paniculata; Andrographis paniculata ethanolic extract; andrographolide; Biological Availability; blood chemistry; COVID-19 Drug Treatment; Diterpenes - administration & dosage; Diterpenes - pharmacokinetics; Dose-Response Relationship, Drug; Ethanol - chemistry; Female; Healthy Volunteers; Humans; Male; Middle Aged; pharmacokinetics; Plant Extracts - administration & dosage; Plant Extracts - adverse effects; Plant Extracts - pharmacokinetics; safety profiles; Young Adult; blood chemistry; Andrographis paniculata ethanolic extract; pharmacokinetics; safety profiles; andrographolide