Dolichol-phosphate mannose synthase: Structure, function and regulation

• Published in: Biochimica et biophysica acta Vol. 1780; no. 6; pp. 861 - 868
• Main Authors: Maeda, Yusuke, Kinoshita, Taroh
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2008
• Subjects: Animals; Biosynthesis; Dolichol Monophosphate Mannose - metabolism; Dolichol-phosphate mannose; DPM1; Endoplasmic Reticulum - enzymology; Endoplasmic Reticulum - genetics; Glucose - genetics; Glucose - metabolism; Glycosylation; Golgi Apparatus - enzymology; Golgi Apparatus - genetics; Humans; Mannose - genetics; Mannose - metabolism; Mannosyltransferases - chemistry; Mannosyltransferases - genetics; Mannosyltransferases - metabolism; Protein Modification, Translational - physiology; DPM1; Dolichol-phosphate mannose; Biosynthesis; Glycosylation

Glycosylation is the major modification of proteins, and alters their structures, functions and localizations. Glycosylation of secretory and surface proteins takes place in the endoplasmic reticulum and Golgi apparatus in eukaryotic cells and is classified into four modification pathways, namely N-...