Downregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration - Tao, Chen-Yang; Wu, Xiao-Ling; Song, Shu-Shu; Tang, Zheng; Zhou, Yu-Fu; Tian, Meng-Xin; Jiang, Xi-Fei; Fang, Yuan; Zhu, Gui-Qi; Huang, Run; Qu, Wei-Feng; Gao, Jun; et al. (Cellular oncology (Dordrecht), 2024)
Keywords: 1-Phosphatidylinositol 3-kinase; AKT protein; Animals; Antitumor activity; Biomedical and Life Sciences; Biomedicine; Cancer Research; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell Line, Tumor; Cell migration; Cell Movement - genetics; Down-regulation; Down-Regulation - genetics; Endoplasmic reticulum; Female; Gene Expression Regulation, Neoplastic; Glutathione; Glutathione Peroxidase - genetics; Glutathione Peroxidase - metabolism; Heat shock proteins; Hepatocellular carcinoma; Hsc70 protein; Humans; Immunoprecipitation; Kinases; KLF4 protein; Kruppel-Like Factor 4; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Male; Mass spectroscopy; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - pathology; Oct-4 protein; Oncology; Pathology; Phosphorylation; Pluripotency; Protein arrays; Protein transport; Proteins; Proto-Oncogene Proteins c-akt - metabolism; Signal transduction; Signal Transduction - genetics; Therapeutic targets; Transcriptomes; Tumors; GPX8; Hepatocellular carcinoma; Hsc70; Migration; Tumor stemness