Circulating Monocytes in HIV-1-Infected Viremic Subjects Exhibit an Antiapoptosis Gene Signature and Virus- and Host-Mediated Apoptosis Resistance

• Published in: The Journal of immunology (1950) Vol. 182; no. 7; pp. 4459 - 4470
• Main Authors: Giri, Malavika S, Nebozyhn, Michael, Raymond, Andrea, Gekonge, Bethsebah, Hancock, Aidan, Creer, Shenoa, Nicols, Calen, Yousef, Malik, Foulkes, Andrea S, Mounzer, Karam, Shull, Jane, Silvestri, Guido, Kostman, Jay, Collman, Ronald G, Showe, Louise, Montaner, Luis J
• Format: Journal Article
• Language: English
• Published: England Am Assoc Immnol 01.04.2009
• Subjects: Adult; Apoptosis - genetics; Caspase 3 - metabolism; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - pathology; CD4-Positive T-Lymphocytes - virology; CD40 Ligand - genetics; Cluster Analysis; Extracellular Signal-Regulated MAP Kinases - genetics; Female; Gene Expression Profiling; HIV Infections - genetics; HIV Infections - immunology; HIV Infections - pathology; HIV-1 - immunology; Humans; Male; Middle Aged; Monocytes - immunology; Monocytes - pathology; Monocytes - virology; Oligonucleotide Array Sequence Analysis; Receptors, CCR5 - immunology; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction - genetics; Tumor Necrosis Factor-alpha - genetics; Tumor Suppressor Protein p53 - genetics; Viremia - genetics; Viremia - immunology

Mechanisms that may allow circulating monocytes to persist as CD4 T cells diminish in HIV-1 infection have not been investigated. We have characterized steady-state gene expression signatures in circulating monocytes from HIV-infected subjects and have identified a stable antiapoptosis gene signatur...