Acylated- and unacylated ghrelin during an oral glucose tolerance test in humans at risk for type 2 diabetes mellitus

• Published in: International Journal of Obesity Vol. 47; no. 9; pp. 825 - 832
• Main Authors: Wolf, Magnus, Heni, Martin, Hennige, Anita M., Sippel, Katrin, Cegan, Alexander, Higuita, Lina María Serna, Martus, Peter, Häring, Hans-Ulrich, Fritsche, Andreas, Peter, Andreas
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2023; Nature Publishing Group
• Subjects: 631/45/776/198; 692/163/2743/2815; 692/163/2743/393; 82/1; Acylation; Biological activity; Body weight; Chromium; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Epidemiology; Fasting; Ghrelin; Glucose; Glucose tolerance; Health Promotion and Disease Prevention; Homeostasis; Insulin; Insulin resistance; Internal Medicine; Laboratory testing; Medicine; Medicine & Public Health; Metabolic Diseases; Multivariate analysis; Obesity; Post-translation; Public Health

Background/Objectives The orexigenic peptide hormone ghrelin has been implicated in the pathophysiology of obesity and type 2 diabetes mellitus through its effects on nutrient homeostasis. Ghrelin is subject to a unique post-translational acyl modification regulating its biochemical activity. Subjec...