Distinct Molecular Basis for Differential Sensitivity of the Serotonin Type 3A Receptor to Ethanol in the Absence and Presence of Agonist

• Published in: The Journal of biological chemistry Vol. 277; no. 48; pp. 46256 - 46264
• Main Authors: Zhang, Li, Hosoi, Masako, Fukuzawa, Misa, Sun, Hui, Rawlings, Robert R., Weight, Forrest F.
• Format: Journal Article
• Language: English
• Published: United States American Society for Biochemistry and Molecular Biology 29.11.2002
• Subjects: Amino Acid Sequence; Animals; Ethanol - pharmacology; Humans; Ion Channel Gating - drug effects; Ligands; Mice; Mutagenesis, Site-Directed; Receptors, Serotonin - drug effects; Receptors, Serotonin - genetics; Receptors, Serotonin, 5-HT3; Serotonin Receptor Agonists - pharmacology

Ethanol can potentiate serotonin type 3 (5-HT 3 ) receptor-mediated responses in various neurons and in cells expressing 5-HT 3A receptors. However, the molecular basis for alcohol modulation of 5-HT 3 receptor function has not been determined. Here we report that point mutations of the arginine at...