Melanin-Concentrating Hormone-1 Receptor Modulates Neuroendocrine, Behavioral, and Corticolimbic Neurochemical Stress Responses in Mice

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 31; no. 6; pp. 1135 - 1145
• Main Authors: Smith, Daniel G, Davis, Richard J, Rorick-Kehn, Linda, Morin, Michelle, Witkin, Jeffrey M, McKinzie, David L, Nomikos, George G, Gehlert, Donald R
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.06.2006
• Subjects: Acetylcholine - metabolism; Adrenocorticotropic Hormone - blood; Alprazolam - pharmacology; Animals; Anti-Anxiety Agents - pharmacology; Behavior, Animal - drug effects; Behavior, Animal - physiology; Body Temperature - drug effects; Brain Chemistry - drug effects; Brain Chemistry - physiology; Corticosterone - blood; Dose-Response Relationship, Drug; Hypothalamic Hormones - administration & dosage; Male; Maze Learning - drug effects; Maze Learning - physiology; Melanins - administration & dosage; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurosecretory Systems - drug effects; Neurosecretory Systems - metabolism; Pituitary Hormones - administration & dosage; Random Allocation; Receptors, Somatostatin - antagonists & inhibitors; Receptors, Somatostatin - deficiency; Receptors, Somatostatin - physiology; Stress, Physiological - metabolism; Stress, Physiological - physiopathology; Stress, Physiological - psychology

Repeated exposure to stressful conditions is linked to the etiology of affective disorders. The melanin-concentrating hormone-1 receptor (MCHR1) may be a novel mechanism that is involved in the modulation of stress responses and affective states. The role of MCHR1 in neuroendocrine, behavioral, and...