The Role of Thioredoxin System in Shank3 Mouse Model of Autism

• Published in: Journal of molecular neuroscience Vol. 74; no. 4; p. 90
• Main Authors: Bazbaz, Wisam, Kartawy, Maryam, Hamoudi, Wajeha, Ojha, Shashank Kumar, Khaliulin, Igor, Amal, Haitham
• Format: Journal Article
• Language: English
• Published: New York Springer US 30.09.2024; Springer Nature B.V
• Subjects: Animals; Autism; Autism Spectrum Disorder - genetics; Autism Spectrum Disorder - metabolism; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cell Line, Tumor; Cells, Cultured; Disease Models, Animal; Humans; In vivo methods and tests; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins - genetics; Microfilament Proteins - metabolism; Molecular modelling; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Neurochemistry; Neurodevelopmental disorders; Neurology; Neurons - metabolism; Neurosciences; Neurotransmission; NF-E2-Related Factor 2 - genetics; NF-E2-Related Factor 2 - metabolism; Nitric oxide; Oxidative Stress; Phenotypes; Proteins; Proteomics; Social behavior; Therapeutic targets; Thioredoxin; Thioredoxins - genetics; Thioredoxins - metabolism; Peroxiredoxin; Oxidative stress; Neuroscience; Nitric oxide; Developmental disorders; Thioredoxin; Nitrosative stress; Autism spectrum disorder

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by difficulties in social interaction and communication, repetitive behaviors, and restricted interests. Unfortunately, the underlying molecular mechanism behind ASD remains unknown. It has been reported that oxida...