Plasma endocannabinoid levels in lean, overweight, and obese humans: relationships to intestinal permeability markers, inflammation, and incretin secretion

• Published in: American journal of physiology: endocrinology and metabolism Vol. 315; no. 4; pp. E489 - E495
• Main Authors: Little, Tanya J, Cvijanovic, Nada, DiPatrizio, Nicholas V, Argueta, Donovan A, Rayner, Christopher K, Feinle-Bisset, Christine, Young, Richard L
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.10.2018
• Series: Endocannabinoids and Cannabinoid Receptors as Regulators of Endocrine Functions and Tissue Metabolism
• Subjects: Adult; Alkaline Phosphatase - genetics; Anandamide; Arachidonic Acids - blood; Biomass; Biopsy; Body mass; Body weight; Cannabinoids; Diet; Dietary Fats - metabolism; Digestive system; Duodenum - metabolism; Endocannabinoids - blood; Female; Gastric Inhibitory Polypeptide - blood; Gene Expression; Glucagon; Glucagon-like peptide 1; Glucagon-Like Peptide 1 - blood; Glycerides - blood; Glycerol; GPI-Linked Proteins - genetics; High fat diet; High-performance liquid chromatography; Humans; Incretins - metabolism; Inflammation; Inflammation - immunology; Intestine; Lipids; Liquid chromatography; Male; Markers; Mass spectrometry; Mass spectroscopy; Microbiomes; Obesity; Obesity - blood; Obesity - immunology; Obesity - metabolism; Occludin - genetics; Oleic acid; Oleic Acids - blood; Overweight; Overweight - blood; Overweight - immunology; Overweight - metabolism; Permeability; Polymerase chain reaction; Polyunsaturated Alkamides - blood; Rodents; Satiety; Secretion; Thinness - blood; Thinness - immunology; Thinness - metabolism; TLR4 protein; Toll-Like Receptor 4 - genetics; Toll-like receptors; Tumor Necrosis Factor-alpha - immunology; Tumor necrosis factor-α; Zonula occludens-1 protein; Zonula Occludens-1 Protein - genetics; inflammation tight-junction proteins; n-acylethanolamines; anandamide; intestinal fat sensors; 2-arachidonylglycerol

Intestinal production of endocannabinoid and oleoylethanolamide (OEA) is impaired in high-fat diet/obese rodents, leading to reduced satiety. Such diets also alter the intestinal microbiome in association with enhanced intestinal permeability and inflammation; however, little is known of these effec...