Anti-apoptotic activity of caffeic acid, ellagic acid and ferulic acid in normal human peripheral blood mononuclear cells: A Bcl-2 independent mechanism

• Published in: Biochimica et biophysica acta Vol. 1760; no. 2; pp. 283 - 289
• Main Authors: Khanduja, Krishan Lal, Avti, Pramod Kumar, Kumar, Surender, Mittal, Nidhi, Sohi, Kiranjit Kaur, Pathak, Chander Mohan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2006
• Subjects: Antioxidants - pharmacology; Apoptosis; Apoptosis - drug effects; Bcl-2; Biphenyl Compounds; Caffeic acid; Caffeic Acids - pharmacology; Coumaric Acids - pharmacology; Ellagic acid; Ellagic Acid - pharmacology; Ferulic acid; Flavonoids - pharmacology; Humans; Hydrogen Peroxide - antagonists & inhibitors; Leukocytes, Mononuclear - drug effects; Lipid Peroxidation - drug effects; Oxidative stress; Oxidative Stress - drug effects; Phenols - pharmacology; Picrates - pharmacology; Polyphenols; Proto-Oncogene Proteins c-bcl-2 - physiology; Bcl-2; Oxidative stress; Ellagic acid; Caffeic acid; Apoptosis; Ferulic acid

Polyphenols have been shown to induce apoptosis in a variety of tumor cells including leukemia both in vitro and in vivo. However, their action on normal human peripheral blood mononuclear cells (PBMCs) during oxidative stress remains to be explored. In this study, we have evaluated the anti-apoptot...