Circulating HIV-1 Integrase Genotypes in Tanzania: Implication on the Introduction of Integrase Inhibitors-Based Antiretroviral Therapy Regimen

• Published in: AIDS research and human retroviruses
• Main Authors: Masoud, Salim, Kamori, Doreen, Barabona, Godfrey, Mahiti, Macdonald, Sunguya, Bruno, Lyamuya, Eligius, Ueno, Takamasa
• Format: Journal Article
• Language: English
• Published: United States 01.06.2020
• Subjects: HIV-1; mutations; integrase; antiretroviral therapy; resistance

Tanzania has recently adapted World Health Organization antiretroviral guidelines that include integrase strand transfer inhibitors (INSTIs) in the first-line regimen. However, there is lack of evidence on integrase (IN) gene polymorphisms in viral strains circulating in Tanzania. In this study, we...