High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis - Uchida, Kanji; Nakata, Koh; Trapnell, Bruce C.; Terakawa, Takahiro; Hamano, Emi; Mikami, Ayako; Matsushita, Ikumi; Seymour, John F.; Oh-eda, Masayoshi; Ishige, Ikuo; Eishi, Yoshinobu; Kitamura, Takayuki; et al. (Blood, 2004)
Keywords: Adult; Aged; Animals; Antibody Affinity; Antibody Specificity; Antigen-Antibody Complex - metabolism; Autoantibodies - metabolism; Biological and medical sciences; Bronchoalveolar Lavage Fluid - cytology; Bronchoalveolar Lavage Fluid - immunology; Case-Control Studies; Cell Division; Cells, Cultured; Epitopes - chemistry; Female; General aspects; Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors; Granulocyte-Macrophage Colony-Stimulating Factor - chemistry; Granulocyte-Macrophage Colony-Stimulating Factor - immunology; Humans; Immunopathology; Lung - immunology; Macrophages, Alveolar - immunology; Macrophages, Alveolar - pathology; Male; Medical sciences; Mice; Middle Aged; Models, Molecular; Neutralization Tests; Pneumology; Protein Conformation; Pulmonary Alveolar Proteinosis - etiology; Pulmonary Alveolar Proteinosis - immunology; Respiratory system : syndromes and miscellaneous diseases; Autoimmunity; Human; Lung disease; Respiratory disease; Antibody; Pathogenesis; Cytokine; Idiopathic; Autoantibody; Respiratory system; Pulmonary alveolar proteinosis; Pulmonary surfactant; Polypeptide; Granulocyte macrophage colony stimulating factor