Kank proteins: A new family of ankyrin-repeat domain-containing proteins
The human Kank gene was found as a candidate tumor suppressor for renal cell carcinoma, and encodes an ankyrin-repeat domain-containing protein, Kank. Here, we report a new family of proteins consisting of three Kank (Kank1)-associated members, Kank2, Kank3 and Kank4, which were found by domain and...
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| Published in | Biochimica et biophysica acta Vol. 1780; no. 2; pp. 128 - 133 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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Elsevier B.V
01.02.2008
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| Abstract | The human Kank gene was found as a candidate tumor suppressor for renal cell carcinoma, and encodes an ankyrin-repeat domain-containing protein, Kank. Here, we report a new family of proteins consisting of three Kank (Kank1)-associated members, Kank2, Kank3 and Kank4, which were found by domain and phylogenetic analyses. Besides the conserved ankyrin-repeat and coiled-coil domains, there was a conserved motif at the N-terminal (KN motif) containing potential motifs for nuclear localization and export signals. Gene expression of these genes was examined by RT-PCR at the mRNA level and by Western blotting and immunostaining at the protein level. Kank family genes showed variations in the expression level among tissues and kidney cell lines. Furthermore, the results of overexpression of these genes in NIH3T3 cells suggest that all of these family proteins have an identical role in the formation of actin stress fibers. |
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| AbstractList | The human Kank gene was found as a candidate tumor suppressor for renal cell carcinoma, and encodes an ankyrin-repeat domain-containing protein, Kank. Here, we report a new family of proteins consisting of three Kank (Kank1)-associated members, Kank2, Kank3 and Kank4, which were found by domain and phylogenetic analyses. Besides the conserved ankyrin-repeat and coiled-coil domains, there was a conserved motif at the N-terminal (KN motif) containing potential motifs for nuclear localization and export signals. Gene expression of these genes was examined by RT-PCR at the mRNA level and by Western blotting and immunostaining at the protein level. Kank family genes showed variations in the expression level among tissues and kidney cell lines. Furthermore, the results of overexpression of these genes in NIH3T3 cells suggest that all of these family proteins have an identical role in the formation of actin stress fibers. The human Kank gene was found as a candidate tumor suppressor for renal cell carcinoma, and encodes an ankyrin-repeat domain-containing protein, Kank. Here, we report a new family of proteins consisting of three Kank (Kank1)-associated members, Kank2, Kank3 and Kank4, which were found by domain and phylogenetic analyses. Besides the conserved ankyrin-repeat and coiled-coil domains, there was a conserved motif at the N-terminal (KN motif) containing potential motifs for nuclear localization and export signals. Gene expression of these genes was examined by RT-PCR at the mRNA level and by Western blotting and immunostaining at the protein level. Kank family genes showed variations in the expression level among tissues and kidney cell lines. Furthermore, the results of overexpression of these genes in NIH3T3 cells suggest that all of these family proteins have an identical role in the formation of actin stress fibers.The human Kank gene was found as a candidate tumor suppressor for renal cell carcinoma, and encodes an ankyrin-repeat domain-containing protein, Kank. Here, we report a new family of proteins consisting of three Kank (Kank1)-associated members, Kank2, Kank3 and Kank4, which were found by domain and phylogenetic analyses. Besides the conserved ankyrin-repeat and coiled-coil domains, there was a conserved motif at the N-terminal (KN motif) containing potential motifs for nuclear localization and export signals. Gene expression of these genes was examined by RT-PCR at the mRNA level and by Western blotting and immunostaining at the protein level. Kank family genes showed variations in the expression level among tissues and kidney cell lines. Furthermore, the results of overexpression of these genes in NIH3T3 cells suggest that all of these family proteins have an identical role in the formation of actin stress fibers. |
| Author | Zhu, Yun Kiyama, Ryoiti Wang, Yong Kakinuma, Naoto |
| Author_xml | – sequence: 1 givenname: Yun surname: Zhu fullname: Zhu, Yun – sequence: 2 givenname: Naoto surname: Kakinuma fullname: Kakinuma, Naoto – sequence: 3 givenname: Yong surname: Wang fullname: Wang, Yong – sequence: 4 givenname: Ryoiti surname: Kiyama fullname: Kiyama, Ryoiti email: kiyama.r@aist.go.jp |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17996375$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Actin stress fiber Amino Acid Sequence Animals Ankyrin Repeat Coiled-coil domain Gene Expression Genome Humans Kank family protein Mice Molecular Sequence Data NIH 3T3 Cells Phylogeny Rats Tumor Suppressor Proteins - chemistry Tumor Suppressor Proteins - classification Tumor Suppressor Proteins - genetics |
| Title | Kank proteins: A new family of ankyrin-repeat domain-containing proteins |
| URI | https://dx.doi.org/10.1016/j.bbagen.2007.09.017 https://www.ncbi.nlm.nih.gov/pubmed/17996375 https://www.proquest.com/docview/70241369 |
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