Engineering the sialic acid in organs of mice using N-propanoylmannosamine
Sialic acids play an important role during development, regeneration and pathogenesis. The precursor of most physiological sialic acids, such as N-acetylneuraminic acid is N-acetyl- d-mannosamine. Application of the novel N-propanoylmannosamine leads to the incorporation of the new sialic acid N-pro...
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| Published in | Biochimica et biophysica acta Vol. 1770; no. 2; pp. 297 - 306 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.02.2007
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| Subjects | |
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| Abstract | Sialic acids play an important role during development, regeneration and pathogenesis. The precursor of most physiological sialic acids, such as
N-acetylneuraminic acid is
N-acetyl-
d-mannosamine. Application of the novel
N-propanoylmannosamine leads to the incorporation of the new sialic acid
N-propanoylneuraminic acid into cell surface glycoconjugates. Here we analyzed the modified sialylation of several organs with
N-propanoylneuraminic acid in mice. By using peracetylated
N-propanoylmannosamine, we were able to replace
in vivo between 1% (brain) and 68% (heart) of physiological sialic acids by
N-propanoylneuraminic acid. The possibility to modify cell surfaces with engineered sialic acids
in vivo offers the opportunity to target therapeutic agents to sites of high sialic acid concentration in a variety of tumors. Furthermore, we demonstrated that application of
N-propanoylmannosamine leads to a decrease in the polysialylation of the neural cell adhesion molecule
in vivo, which is a marker of poor prognosis for some tumors with high metastatic potential. |
|---|---|
| AbstractList | Sialic acids play an important role during development, regeneration and pathogenesis. The precursor of most physiological sialic acids, such as N-acetylneuraminic acid is N-acetyl-D-mannosamine. Application of the novel N-propanoylmannosamine leads to the incorporation of the new sialic acid N-propanoylneuraminic acid into cell surface glycoconjugates. Here we analyzed the modified sialylation of several organs with N-propanoylneuraminic acid in mice. By using peracetylated N-propanoylmannosamine, we were able to replace in vivo between 1% (brain) and 68% (heart) of physiological sialic acids by N-propanoylneuraminic acid. The possibility to modify cell surfaces with engineered sialic acids in vivo offers the opportunity to target therapeutic agents to sites of high sialic acid concentration in a variety of tumors. Furthermore, we demonstrated that application of N-propanoylmannosamine leads to a decrease in the polysialylation of the neural cell adhesion molecule in vivo, which is a marker of poor prognosis for some tumors with high metastatic potential.Sialic acids play an important role during development, regeneration and pathogenesis. The precursor of most physiological sialic acids, such as N-acetylneuraminic acid is N-acetyl-D-mannosamine. Application of the novel N-propanoylmannosamine leads to the incorporation of the new sialic acid N-propanoylneuraminic acid into cell surface glycoconjugates. Here we analyzed the modified sialylation of several organs with N-propanoylneuraminic acid in mice. By using peracetylated N-propanoylmannosamine, we were able to replace in vivo between 1% (brain) and 68% (heart) of physiological sialic acids by N-propanoylneuraminic acid. The possibility to modify cell surfaces with engineered sialic acids in vivo offers the opportunity to target therapeutic agents to sites of high sialic acid concentration in a variety of tumors. Furthermore, we demonstrated that application of N-propanoylmannosamine leads to a decrease in the polysialylation of the neural cell adhesion molecule in vivo, which is a marker of poor prognosis for some tumors with high metastatic potential. Sialic acids play an important role during development, regeneration and pathogenesis. The precursor of most physiological sialic acids, such as N-acetylneuraminic acid is N-acetyl-D-mannosamine. Application of the novel N-propanoylmannosamine leads to the incorporation of the new sialic acid N-propanoylneuraminic acid into cell surface glycoconjugates. Here we analyzed the modified sialylation of several organs with N-propanoylneuraminic acid in mice. By using peracetylated N-propanoylmannosamine, we were able to replace in vivo between 1% (brain) and 68% (heart) of physiological sialic acids by N-propanoylneuraminic acid. The possibility to modify cell surfaces with engineered sialic acids in vivo offers the opportunity to target therapeutic agents to sites of high sialic acid concentration in a variety of tumors. Furthermore, we demonstrated that application of N-propanoylmannosamine leads to a decrease in the polysialylation of the neural cell adhesion molecule in vivo, which is a marker of poor prognosis for some tumors with high metastatic potential. Sialic acids play an important role during development, regeneration and pathogenesis. The precursor of most physiological sialic acids, such as N-acetylneuraminic acid is N-acetyl- d-mannosamine. Application of the novel N-propanoylmannosamine leads to the incorporation of the new sialic acid N-propanoylneuraminic acid into cell surface glycoconjugates. Here we analyzed the modified sialylation of several organs with N-propanoylneuraminic acid in mice. By using peracetylated N-propanoylmannosamine, we were able to replace in vivo between 1% (brain) and 68% (heart) of physiological sialic acids by N-propanoylneuraminic acid. The possibility to modify cell surfaces with engineered sialic acids in vivo offers the opportunity to target therapeutic agents to sites of high sialic acid concentration in a variety of tumors. Furthermore, we demonstrated that application of N-propanoylmannosamine leads to a decrease in the polysialylation of the neural cell adhesion molecule in vivo, which is a marker of poor prognosis for some tumors with high metastatic potential. |
| Author | Reutter, Werner Zimmermann-Kordmann, Martin Horstkorte, Rüdiger Gagiannis, Daniel Gossrau, Reinhart |
| Author_xml | – sequence: 1 givenname: Daniel surname: Gagiannis fullname: Gagiannis, Daniel organization: Institut für Biochemie und Molekularbiologie, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Arnimallee 22, 14195 Berlin-Dahlem, Germany – sequence: 2 givenname: Reinhart surname: Gossrau fullname: Gossrau, Reinhart organization: Institut für Integrative Neuroanatomie, Charité-Universitätsmedizin Berlin, Campus Mitte, Philippstr. 12’ 10117 Berlin, Germany – sequence: 3 givenname: Werner surname: Reutter fullname: Reutter, Werner organization: Institut für Biochemie und Molekularbiologie, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Arnimallee 22, 14195 Berlin-Dahlem, Germany – sequence: 4 givenname: Martin surname: Zimmermann-Kordmann fullname: Zimmermann-Kordmann, Martin organization: Institut für Biochemie und Molekularbiologie, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Arnimallee 22, 14195 Berlin-Dahlem, Germany – sequence: 5 givenname: Rüdiger surname: Horstkorte fullname: Horstkorte, Rüdiger email: ruediger.horstkorte@medizin.uni-halle.de organization: Institut für Biochemie und Molekularbiologie, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Arnimallee 22, 14195 Berlin-Dahlem, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17110045$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.yexcr.2004.04.014 10.1084/jem.185.11.1929 10.1135/cccc20041829 10.1002/ijc.2910570707 10.1006/bbrc.2001.4750 10.1006/bbrc.1998.9650 10.1074/jbc.270.39.22685 10.1016/0168-0102(93)90111-3 10.1016/j.febslet.2005.08.013 10.1021/cr000407m 10.1016/S0008-6215(00)90623-2 10.1073/pnas.82.4.1194 10.1073/pnas.072066199 10.1016/0006-291X(83)91490-0 10.1074/jbc.270.24.14628 10.1523/JNEUROSCI.22-20-08869.2002 10.1021/ja01535a062 10.1002/eji.200425691 10.1073/pnas.0506855103 10.1093/glycob/2.1.5 10.1074/jbc.273.30.19146 10.1074/jbc.270.3.1308 10.1016/0306-4522(94)90209-7 10.1016/S0022-3468(98)90488-2 10.1158/1078-0432.CCR-03-0101 10.1093/glycob/10.1.11 10.1002/jnr.490200304 10.1096/fasebj.11.4.9068613 10.1016/S0021-9258(18)41874-1 10.1038/nchembio0605-13 10.1002/bit.10901 10.1074/jbc.C000573200 10.1038/373715a0 10.1126/science.276.5315.1125 10.1126/science.1062192 10.1038/nature02791 10.1073/pnas.92.8.3323 10.1073/pnas.92.15.7031 10.1111/j.1530-0277.1998.tb03902.x 10.1016/S0300-9084(01)01303-7 |
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| Keywords | Sialic acid Neural cell adhesion molecule Biochemical engineering Polysialic acid |
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| References | Horstkorte, Lee, Lucka, Danker, Reutter (bib10) 2001; 283 Roneis (bib30) 1968 Santoni, Goridis, Fontecilla-Camps (bib44) 1988; 20 Fukuda (bib46) 1996; 56 Seki, Arai (bib21) 1993; 17 Mahal, Yarema, Bertozzi (bib6) 1997; 276 Troy (bib45) 1992; 1 Ghosh, Ender, Hale (bib41) 1998; 22 Schwarzkopf, Knobeloch, Rohde, Hinderlich, Wiechens, Lucka, Horak, Reutter, Horstkorte (bib33) 2002; 99 Kayser, Zeitler, Kannicht, Grunow, Nuck, Reutter (bib5) 1992; 267 Finne, Finne, Deagostini-Bazin, Goridis (bib43) 1983; 112 Varki (bib3) 1997; 11 Horstkorte, Mühlenhoff, Reutter, Nöhring, Zimmermann-Kordmann, Gerardy-Schahn (bib20) 2004; 298 Pon, Lussier, Yang, Jennings (bib29) 1997; 185 Keppler, Herrmann, von der Lieth, Stehling, Reutter, Pawlita (bib13) 1998; 253 Dube, Prescher, Quang, Bertozzi (bib42) 2006; 103 Angata, Varki (bib2) 2002; 102 Nakayama, Fukuda, Fredette, Ranscht, Fukuda (bib17) 1995; 92 Sarkar, Fritz, Taylor, Esko (bib35) 1995; 92 Reutter, Horstkorte (bib11) 2004; 69 Szele, Dowling, Gonzales, Theveniau, Rougon, Chesselet (bib23) 1994; 60 Jones, Teng, Rhee, Lahar, Baskaran, Yarema (bib36) 2004; 85 Eckhardt, Mühlenhoff, Bethe, Koopman, Frosch, Gerardy-Schahn (bib16) 1995; 373 Yoshida, Kojima, Kurosawa, Hamamoto, Tsuji (bib19) 1995; 270 Mahal, Charter, Angata, Fukuda, Koshland, Bertozzi (bib15) 2001; 294 Schauer, Stoll, Reuter (bib38) 1991; 213 Singer, Klaile, Scheffrahn, Müller, Kammerer, Reutter, Öbrink, Lucka (bib32) 2005; 35 Bork, Reutter, Gerardy-Schahn, Horstkorte (bib34) 2005; 579 Schauer, Kelm, Reuter, Roggentin, Shaw (bib1) 1995 Collins, Fralich, Itonori, Ichikawa, Schnaar (bib8) 2000; 10 Büttner, Kannicht, Schmidt, Löster, Reutter, Lee, Nöhring, Horstkorte (bib14) 2002; 22 Malykh, Schauer, Shaw (bib40) 2001; 83 Michalides, Kwa, Springall, van Zandwijk, Koopman, Hilkens, Mooi (bib22) 1994; 8 Krug, Ragupathi, Ng, Hood, Jennings, Guo, Kris, Miller, Pizzo, Tyson, Baez, Livingston (bib27) 2004; 10 Prescher, Bertozzi (bib39) 2005; 1 Schmidt, Stehling, Schnitzer, Reutter, Horstkorte (bib7) 1998; 273 Keppler, Stehling, Herrmann, Kayser, Grunow, Reutter, Pawlita (bib9) 1995; 270 Liu, Guo, Yang, Sad, Jennings (bib26) 2000; 275 Gluer, Schelp, Gerardy-Schahn, von Schweinitz (bib24) 1998; 33 Tanaka, Otake, Nakagawa, Kawano, Miyahara, Li, Yanagihara, Inui, Oyanagi, Yamada, Nakayama, Fujimoto, Ikenaka, Wada (bib25) 2001; 15 Comb, Roseman (bib4) 1958; 80 Frosch, Gorgen, Boulnois, Timmis, Bitter-Suermann (bib28) 1985; 82 Gossrau, Günther (bib37) 1993 Scheidegger, Sternberg, Roth, Lowe (bib18) 1995; 270 Prescher, Dube, Bertozzi (bib12) 2004; 430 Lojda, Gossrau, Schieble (bib31) 1979 Roneis (10.1016/j.bbagen.2006.09.023_bib30) 1968 Liu (10.1016/j.bbagen.2006.09.023_bib26) 2000; 275 Reutter (10.1016/j.bbagen.2006.09.023_bib11) 2004; 69 Santoni (10.1016/j.bbagen.2006.09.023_bib44) 1988; 20 Keppler (10.1016/j.bbagen.2006.09.023_bib9) 1995; 270 Singer (10.1016/j.bbagen.2006.09.023_bib32) 2005; 35 Jones (10.1016/j.bbagen.2006.09.023_bib36) 2004; 85 Ghosh (10.1016/j.bbagen.2006.09.023_bib41) 1998; 22 Büttner (10.1016/j.bbagen.2006.09.023_bib14) 2002; 22 Collins (10.1016/j.bbagen.2006.09.023_bib8) 2000; 10 Mahal (10.1016/j.bbagen.2006.09.023_bib15) 2001; 294 Pon (10.1016/j.bbagen.2006.09.023_bib29) 1997; 185 Dube (10.1016/j.bbagen.2006.09.023_bib42) 2006; 103 Finne (10.1016/j.bbagen.2006.09.023_bib43) 1983; 112 Varki (10.1016/j.bbagen.2006.09.023_bib3) 1997; 11 Schauer (10.1016/j.bbagen.2006.09.023_bib1) 1995 Horstkorte (10.1016/j.bbagen.2006.09.023_bib10) 2001; 283 Krug (10.1016/j.bbagen.2006.09.023_bib27) 2004; 10 Lojda (10.1016/j.bbagen.2006.09.023_bib31) 1979 Seki (10.1016/j.bbagen.2006.09.023_bib21) 1993; 17 Michalides (10.1016/j.bbagen.2006.09.023_bib22) 1994; 8 Frosch (10.1016/j.bbagen.2006.09.023_bib28) 1985; 82 Nakayama (10.1016/j.bbagen.2006.09.023_bib17) 1995; 92 Fukuda (10.1016/j.bbagen.2006.09.023_bib46) 1996; 56 Eckhardt (10.1016/j.bbagen.2006.09.023_bib16) 1995; 373 Angata (10.1016/j.bbagen.2006.09.023_bib2) 2002; 102 Comb (10.1016/j.bbagen.2006.09.023_bib4) 1958; 80 Sarkar (10.1016/j.bbagen.2006.09.023_bib35) 1995; 92 Prescher (10.1016/j.bbagen.2006.09.023_bib39) 2005; 1 Scheidegger (10.1016/j.bbagen.2006.09.023_bib18) 1995; 270 Bork (10.1016/j.bbagen.2006.09.023_bib34) 2005; 579 Schmidt (10.1016/j.bbagen.2006.09.023_bib7) 1998; 273 Troy (10.1016/j.bbagen.2006.09.023_bib45) 1992; 1 Gluer (10.1016/j.bbagen.2006.09.023_bib24) 1998; 33 Prescher (10.1016/j.bbagen.2006.09.023_bib12) 2004; 430 Szele (10.1016/j.bbagen.2006.09.023_bib23) 1994; 60 Yoshida (10.1016/j.bbagen.2006.09.023_bib19) 1995; 270 Schauer (10.1016/j.bbagen.2006.09.023_bib38) 1991; 213 Kayser (10.1016/j.bbagen.2006.09.023_bib5) 1992; 267 Horstkorte (10.1016/j.bbagen.2006.09.023_bib20) 2004; 298 Mahal (10.1016/j.bbagen.2006.09.023_bib6) 1997; 276 Keppler (10.1016/j.bbagen.2006.09.023_bib13) 1998; 253 Malykh (10.1016/j.bbagen.2006.09.023_bib40) 2001; 83 Gossrau (10.1016/j.bbagen.2006.09.023_bib37) 1993 Tanaka (10.1016/j.bbagen.2006.09.023_bib25) 2001; 15 Schwarzkopf (10.1016/j.bbagen.2006.09.023_bib33) 2002; 99 |
| References_xml | – year: 1993 ident: bib37 article-title: Spurenelemente und Salicylateffekte. Histochemische und biochemische Untersuchungen publication-title: Teratologie: Grundlagen, Methoden und Klinik – volume: 103 start-page: 4819 year: 2006 end-page: 4824 ident: bib42 article-title: Probing mucin-type O-linked glycosylation in living animals publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 82 start-page: 1194 year: 1985 ident: bib28 article-title: NZB mouse system for production of monoclonal antibodies to weak bacterial antigens: isolation of an IgG antibody to the polysaccharide capsules of publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 294 start-page: 380 year: 2001 ident: bib15 article-title: A small-molecule modulator of poly-alpha 2,8-sialic acid expression on cultured neurons and tumor cells publication-title: Science – volume: 1 start-page: 13 year: 2005 end-page: 21 ident: bib39 article-title: Chemistry in living systems publication-title: Nature Chem. Biol. – volume: 267 start-page: 16934 year: 1992 end-page: 16938 ident: bib5 article-title: Biosynthesis of a nonphysiological sialic acid in different rat organs, using N-propanoyl- publication-title: J. Biol. Chem. – volume: 1 start-page: 5 year: 1992 ident: bib45 article-title: Polysialylation: from bacteria to brains publication-title: Glycobiology – volume: 253 start-page: 437 year: 1998 end-page: 442 ident: bib13 article-title: Elongation of the N-acyl side chain of sialic acids in MDCK-II cells inhibits influenza a virus infection publication-title: Biochem. Biophys. Res. Commun. – volume: 33 start-page: 1516 year: 1998 ident: bib24 article-title: Polysialylated neural cell adhesion molecule as a marker for differential diagnosis in pediatric tumors publication-title: J. Pediatr. Surg. – year: 1979 ident: bib31 article-title: Enzyme histochemistry publication-title: A laboratory manual – volume: 270 start-page: 22685 year: 1995 ident: bib18 article-title: A human STX cDNA confers polysialic acid expression in mammalian cells publication-title: J. Biol. Chem. – volume: 22 start-page: 8867 year: 2002 end-page: 8869 ident: bib14 article-title: Biochemical engineering of cell surface sialic acids stimulates axonal growth publication-title: J. Neurosci. – volume: 102 start-page: 439 year: 2002 end-page: 469 ident: bib2 article-title: Chemical diversity in the sialic acids and related alpha-keto acids: an evolutionary perspective publication-title: Chem. Rev. – volume: 10 start-page: 11 year: 2000 end-page: 20 ident: bib8 article-title: Conversion of cellular sialic acid expression from N-acetyl- to N-glycolylneuraminic acid using a synthetic precursor, N-glycolylmannosamine pentaacetate: inhibition of myelin-associated glycoprotein binding to neural cells publication-title: Glycobiology – volume: 273 start-page: 19146 year: 1998 ident: bib7 article-title: Biochemical engineering of neural cell surfaces by the synthetic N-propanoyl-substituted neuraminic acid precursor publication-title: J. Biol. Chem. – volume: 11 start-page: 248 year: 1997 end-page: 255 ident: bib3 article-title: Sialic acids as ligands in recognition phenomena publication-title: FASEB J. – volume: 270 start-page: 1308 year: 1995 ident: bib9 article-title: Biosynthetic modulation of sialic acid-dependent virus-receptor interactions of two primate polyoma viruses publication-title: J. Biol. Chem. – volume: 17 start-page: 265 year: 1993 ident: bib21 article-title: Distribution and possible roles of the highly polysialylated neural cell adhesion molecule (NCAM-H) in the developing and adult central nervous system publication-title: Neurosci. Res. – volume: 99 start-page: 5267 year: 2002 end-page: 5270 ident: bib33 article-title: Sialylation is essential for early development in mice publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 112 start-page: 482 year: 1983 end-page: 487 ident: bib43 article-title: Occurrence of alpha 2–8 linked polysialosyl units in a neural cell adhesion molecule publication-title: Biochem. Biophys. Res. Commun. – volume: 283 start-page: 31 year: 2001 end-page: 35 ident: bib10 article-title: Biochemical engineering of the side chain of sialic acids increases the biological stability of the highly sialylated cell adhesion molecule CEACAM1 publication-title: Biochem. Biophys. Res. Commun. – volume: 69 start-page: 1829 year: 2004 end-page: 1842 ident: bib11 article-title: Inhibition of biosynthesis and biochemical modulation of N-acylneuraminic acid (biochemical engineering of sialoconjugates) publication-title: Collect Czech. Chem. Commun. – volume: 213 start-page: 353 year: 1991 end-page: 359 ident: bib38 article-title: Differences in the amount of N-acetyl- and N-glycocly-neuraminic acid, as well as O-acetylated sialic acids, of fetal and adult bovine tissues publication-title: Carbohydr. Res. – volume: 579 start-page: 5078 year: 2005 end-page: 5079 ident: bib34 article-title: The intracellular concentration of sialic acid regulates the polysialylation of the neural cell adhesion molecule publication-title: FEBS Lett. – volume: 85 start-page: 394 year: 2004 end-page: 405 ident: bib36 article-title: Characterization of the cellular uptake and metabolic conversion of acetylated N-acetylmannosamine (ManNAc) analogues to sialic acids publication-title: Biotechnol. Bioeng. – start-page: 7 year: 1995 end-page: 67 ident: bib1 article-title: Biochemistry and role of sialic acids publication-title: Biology of the Sialic Acids – volume: 15 start-page: 1666 year: 2001 ident: bib25 article-title: Prognostic significance of polysialic acid expression in resected non-small cell lung cancer publication-title: Cancer Res. – volume: 430 start-page: 873 year: 2004 ident: bib12 article-title: Chemical remodelling of cell surfaces in living animals publication-title: Nature – volume: 80 start-page: 497 year: 1958 end-page: 499 ident: bib4 article-title: Composition and enzymatic synthesis of N-acetylneuraminic (sialic) acid publication-title: J. Am. Chem. Soc. – volume: 20 start-page: 304 year: 1988 end-page: 310 ident: bib44 article-title: Molecular modelling of the immunoglobulin-like domains of the neural cell adhesion molecule (NCAM): implications for the positioning of functionally important sugar side chains publication-title: J. Neurosci. Res. – volume: 298 start-page: 268 year: 2004 end-page: 274 ident: bib20 article-title: Selective inhibition of polysialyltransferase ST8SiaII by unnatural sialic acids publication-title: Exp. Cell Res. – volume: 56 start-page: 2237 year: 1996 ident: bib46 article-title: Possible roles of tumor-associated carbohydrate antigens publication-title: Cancer Res. – volume: 185 start-page: 1929 year: 1997 ident: bib29 article-title: N-Propionylated group B meningococcal polysaccharide mimics a unique bactericidal capsular epitope in group B Neisseria meningitidis publication-title: J. Exp. Med. – volume: 8 start-page: 34 year: 1994 ident: bib22 article-title: NCAM and lung cancer publication-title: Int. J. Cancer, Suppl. – volume: 10 start-page: 916 year: 2004 end-page: 923 ident: bib27 article-title: Vaccination of small cell lung cancer patients with polysialic acid or N-propionylated polysialic acid conjugated to keyhole limpet hemocyanin publication-title: Clin. Cancer Res. – volume: 35 start-page: 1949 year: 2005 end-page: 1959 ident: bib32 article-title: CEACAM1 (CD66a) mediates delay of spontaneous and Fas ligand-induced apoptosis in granulocytes publication-title: Eur. J. Immunol. – year: 1968 ident: bib30 article-title: Mikroskopische Technik, 16. Aufl. Oldenburg, München, Wien – volume: 60 start-page: 133 year: 1994 ident: bib23 article-title: Pattern of expression of highly polysialylated neural cell adhesion molecule in the developing and adult rat striatum publication-title: Neuroscience – volume: 83 start-page: 623 year: 2001 ident: bib40 article-title: N-Glycolylneuraminic acid in human tumours publication-title: Biochimie – volume: 22 start-page: 1220 year: 1998 end-page: 1226 ident: bib41 article-title: Long-term ethanol consumption selectively impairs ganglioside pathway in rat brain publication-title: Alcohol.: Clin. Exp. Res. – volume: 270 start-page: 14628 year: 1995 ident: bib19 article-title: Molecular cloning of Sia alpha 2,3Gal beta 1,4GlcNAc alpha 2,8-sialyltransferase from mouse brain publication-title: J. Biol. Chem. – volume: 92 start-page: 7031 year: 1995 ident: bib17 article-title: Expression cloning of a human polysialyltransferase that forms the polysialylated neural cell adhesion molecule present in embryonic brain publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 92 start-page: 3323 year: 1995 end-page: 3327 ident: bib35 article-title: Disaccharide uptake and priming in animal cells: inhibition of sialyl Lewis X by acetylated Gal beta 1→4GlcNAc beta-O-naphthalenemethanol publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 276 start-page: 1125 year: 1997 end-page: 1128 ident: bib6 article-title: Engineering chemical reactivity on cell surfaces through oligosaccharide biosynthesis publication-title: Science – volume: 275 start-page: 32832 year: 2000 end-page: 32836 ident: bib26 article-title: Biochemical engineering of surface alpha 2–8 polysialic acid for immunotargeting tumor cells publication-title: J. Biol. Chem. – volume: 373 start-page: 715 year: 1995 ident: bib16 article-title: Molecular characterization of eukaryotic polysialyltransferase-1 publication-title: Nature – volume: 298 start-page: 268 year: 2004 ident: 10.1016/j.bbagen.2006.09.023_bib20 article-title: Selective inhibition of polysialyltransferase ST8SiaII by unnatural sialic acids publication-title: Exp. Cell Res. doi: 10.1016/j.yexcr.2004.04.014 – volume: 185 start-page: 1929 year: 1997 ident: 10.1016/j.bbagen.2006.09.023_bib29 article-title: N-Propionylated group B meningococcal polysaccharide mimics a unique bactericidal capsular epitope in group B Neisseria meningitidis publication-title: J. Exp. Med. doi: 10.1084/jem.185.11.1929 – year: 1968 ident: 10.1016/j.bbagen.2006.09.023_bib30 – volume: 69 start-page: 1829 year: 2004 ident: 10.1016/j.bbagen.2006.09.023_bib11 article-title: Inhibition of biosynthesis and biochemical modulation of N-acylneuraminic acid (biochemical engineering of sialoconjugates) publication-title: Collect Czech. Chem. Commun. doi: 10.1135/cccc20041829 – volume: 8 start-page: 34 year: 1994 ident: 10.1016/j.bbagen.2006.09.023_bib22 article-title: NCAM and lung cancer publication-title: Int. J. Cancer, Suppl. doi: 10.1002/ijc.2910570707 – volume: 283 start-page: 31 year: 2001 ident: 10.1016/j.bbagen.2006.09.023_bib10 article-title: Biochemical engineering of the side chain of sialic acids increases the biological stability of the highly sialylated cell adhesion molecule CEACAM1 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.2001.4750 – volume: 253 start-page: 437 year: 1998 ident: 10.1016/j.bbagen.2006.09.023_bib13 article-title: Elongation of the N-acyl side chain of sialic acids in MDCK-II cells inhibits influenza a virus infection publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.1998.9650 – volume: 270 start-page: 22685 year: 1995 ident: 10.1016/j.bbagen.2006.09.023_bib18 article-title: A human STX cDNA confers polysialic acid expression in mammalian cells publication-title: J. Biol. Chem. doi: 10.1074/jbc.270.39.22685 – volume: 17 start-page: 265 year: 1993 ident: 10.1016/j.bbagen.2006.09.023_bib21 article-title: Distribution and possible roles of the highly polysialylated neural cell adhesion molecule (NCAM-H) in the developing and adult central nervous system publication-title: Neurosci. Res. doi: 10.1016/0168-0102(93)90111-3 – volume: 579 start-page: 5078 year: 2005 ident: 10.1016/j.bbagen.2006.09.023_bib34 article-title: The intracellular concentration of sialic acid regulates the polysialylation of the neural cell adhesion molecule publication-title: FEBS Lett. doi: 10.1016/j.febslet.2005.08.013 – volume: 102 start-page: 439 year: 2002 ident: 10.1016/j.bbagen.2006.09.023_bib2 article-title: Chemical diversity in the sialic acids and related alpha-keto acids: an evolutionary perspective publication-title: Chem. Rev. doi: 10.1021/cr000407m – volume: 213 start-page: 353 year: 1991 ident: 10.1016/j.bbagen.2006.09.023_bib38 article-title: Differences in the amount of N-acetyl- and N-glycocly-neuraminic acid, as well as O-acetylated sialic acids, of fetal and adult bovine tissues publication-title: Carbohydr. Res. doi: 10.1016/S0008-6215(00)90623-2 – volume: 82 start-page: 1194 year: 1985 ident: 10.1016/j.bbagen.2006.09.023_bib28 article-title: NZB mouse system for production of monoclonal antibodies to weak bacterial antigens: isolation of an IgG antibody to the polysaccharide capsules of Escherichia coli K1 and group B meningococci publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.82.4.1194 – volume: 99 start-page: 5267 year: 2002 ident: 10.1016/j.bbagen.2006.09.023_bib33 article-title: Sialylation is essential for early development in mice publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.072066199 – volume: 112 start-page: 482 year: 1983 ident: 10.1016/j.bbagen.2006.09.023_bib43 article-title: Occurrence of alpha 2–8 linked polysialosyl units in a neural cell adhesion molecule publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/0006-291X(83)91490-0 – volume: 270 start-page: 14628 year: 1995 ident: 10.1016/j.bbagen.2006.09.023_bib19 article-title: Molecular cloning of Sia alpha 2,3Gal beta 1,4GlcNAc alpha 2,8-sialyltransferase from mouse brain publication-title: J. Biol. Chem. doi: 10.1074/jbc.270.24.14628 – volume: 22 start-page: 8867 year: 2002 ident: 10.1016/j.bbagen.2006.09.023_bib14 article-title: Biochemical engineering of cell surface sialic acids stimulates axonal growth publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.22-20-08869.2002 – volume: 80 start-page: 497 year: 1958 ident: 10.1016/j.bbagen.2006.09.023_bib4 article-title: Composition and enzymatic synthesis of N-acetylneuraminic (sialic) acid publication-title: J. Am. Chem. Soc. doi: 10.1021/ja01535a062 – volume: 15 start-page: 1666 year: 2001 ident: 10.1016/j.bbagen.2006.09.023_bib25 article-title: Prognostic significance of polysialic acid expression in resected non-small cell lung cancer publication-title: Cancer Res. – volume: 35 start-page: 1949 year: 2005 ident: 10.1016/j.bbagen.2006.09.023_bib32 article-title: CEACAM1 (CD66a) mediates delay of spontaneous and Fas ligand-induced apoptosis in granulocytes publication-title: Eur. J. Immunol. doi: 10.1002/eji.200425691 – volume: 103 start-page: 4819 year: 2006 ident: 10.1016/j.bbagen.2006.09.023_bib42 article-title: Probing mucin-type O-linked glycosylation in living animals publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0506855103 – volume: 1 start-page: 5 year: 1992 ident: 10.1016/j.bbagen.2006.09.023_bib45 article-title: Polysialylation: from bacteria to brains publication-title: Glycobiology doi: 10.1093/glycob/2.1.5 – volume: 273 start-page: 19146 year: 1998 ident: 10.1016/j.bbagen.2006.09.023_bib7 article-title: Biochemical engineering of neural cell surfaces by the synthetic N-propanoyl-substituted neuraminic acid precursor publication-title: J. Biol. Chem. doi: 10.1074/jbc.273.30.19146 – volume: 270 start-page: 1308 year: 1995 ident: 10.1016/j.bbagen.2006.09.023_bib9 article-title: Biosynthetic modulation of sialic acid-dependent virus-receptor interactions of two primate polyoma viruses publication-title: J. Biol. Chem. doi: 10.1074/jbc.270.3.1308 – volume: 60 start-page: 133 year: 1994 ident: 10.1016/j.bbagen.2006.09.023_bib23 article-title: Pattern of expression of highly polysialylated neural cell adhesion molecule in the developing and adult rat striatum publication-title: Neuroscience doi: 10.1016/0306-4522(94)90209-7 – volume: 33 start-page: 1516 year: 1998 ident: 10.1016/j.bbagen.2006.09.023_bib24 article-title: Polysialylated neural cell adhesion molecule as a marker for differential diagnosis in pediatric tumors publication-title: J. Pediatr. Surg. doi: 10.1016/S0022-3468(98)90488-2 – volume: 10 start-page: 916 year: 2004 ident: 10.1016/j.bbagen.2006.09.023_bib27 article-title: Vaccination of small cell lung cancer patients with polysialic acid or N-propionylated polysialic acid conjugated to keyhole limpet hemocyanin publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-03-0101 – volume: 10 start-page: 11 year: 2000 ident: 10.1016/j.bbagen.2006.09.023_bib8 article-title: Conversion of cellular sialic acid expression from N-acetyl- to N-glycolylneuraminic acid using a synthetic precursor, N-glycolylmannosamine pentaacetate: inhibition of myelin-associated glycoprotein binding to neural cells publication-title: Glycobiology doi: 10.1093/glycob/10.1.11 – volume: 20 start-page: 304 year: 1988 ident: 10.1016/j.bbagen.2006.09.023_bib44 article-title: Molecular modelling of the immunoglobulin-like domains of the neural cell adhesion molecule (NCAM): implications for the positioning of functionally important sugar side chains publication-title: J. Neurosci. Res. doi: 10.1002/jnr.490200304 – start-page: 7 year: 1995 ident: 10.1016/j.bbagen.2006.09.023_bib1 article-title: Biochemistry and role of sialic acids – volume: 11 start-page: 248 year: 1997 ident: 10.1016/j.bbagen.2006.09.023_bib3 article-title: Sialic acids as ligands in recognition phenomena publication-title: FASEB J. doi: 10.1096/fasebj.11.4.9068613 – volume: 267 start-page: 16934 year: 1992 ident: 10.1016/j.bbagen.2006.09.023_bib5 article-title: Biosynthesis of a nonphysiological sialic acid in different rat organs, using N-propanoyl-d-hexosamines as precursors publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)41874-1 – volume: 1 start-page: 13 year: 2005 ident: 10.1016/j.bbagen.2006.09.023_bib39 article-title: Chemistry in living systems publication-title: Nature Chem. Biol. doi: 10.1038/nchembio0605-13 – volume: 85 start-page: 394 year: 2004 ident: 10.1016/j.bbagen.2006.09.023_bib36 article-title: Characterization of the cellular uptake and metabolic conversion of acetylated N-acetylmannosamine (ManNAc) analogues to sialic acids publication-title: Biotechnol. Bioeng. doi: 10.1002/bit.10901 – volume: 275 start-page: 32832 year: 2000 ident: 10.1016/j.bbagen.2006.09.023_bib26 article-title: Biochemical engineering of surface alpha 2–8 polysialic acid for immunotargeting tumor cells publication-title: J. Biol. Chem. doi: 10.1074/jbc.C000573200 – volume: 373 start-page: 715 year: 1995 ident: 10.1016/j.bbagen.2006.09.023_bib16 article-title: Molecular characterization of eukaryotic polysialyltransferase-1 publication-title: Nature doi: 10.1038/373715a0 – year: 1979 ident: 10.1016/j.bbagen.2006.09.023_bib31 article-title: Enzyme histochemistry – year: 1993 ident: 10.1016/j.bbagen.2006.09.023_bib37 article-title: Spurenelemente und Salicylateffekte. Histochemische und biochemische Untersuchungen – volume: 56 start-page: 2237 year: 1996 ident: 10.1016/j.bbagen.2006.09.023_bib46 article-title: Possible roles of tumor-associated carbohydrate antigens publication-title: Cancer Res. – volume: 276 start-page: 1125 year: 1997 ident: 10.1016/j.bbagen.2006.09.023_bib6 article-title: Engineering chemical reactivity on cell surfaces through oligosaccharide biosynthesis publication-title: Science doi: 10.1126/science.276.5315.1125 – volume: 294 start-page: 380 year: 2001 ident: 10.1016/j.bbagen.2006.09.023_bib15 article-title: A small-molecule modulator of poly-alpha 2,8-sialic acid expression on cultured neurons and tumor cells publication-title: Science doi: 10.1126/science.1062192 – volume: 430 start-page: 873 year: 2004 ident: 10.1016/j.bbagen.2006.09.023_bib12 article-title: Chemical remodelling of cell surfaces in living animals publication-title: Nature doi: 10.1038/nature02791 – volume: 92 start-page: 3323 year: 1995 ident: 10.1016/j.bbagen.2006.09.023_bib35 article-title: Disaccharide uptake and priming in animal cells: inhibition of sialyl Lewis X by acetylated Gal beta 1→4GlcNAc beta-O-naphthalenemethanol publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.92.8.3323 – volume: 92 start-page: 7031 year: 1995 ident: 10.1016/j.bbagen.2006.09.023_bib17 article-title: Expression cloning of a human polysialyltransferase that forms the polysialylated neural cell adhesion molecule present in embryonic brain publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.92.15.7031 – volume: 22 start-page: 1220 year: 1998 ident: 10.1016/j.bbagen.2006.09.023_bib41 article-title: Long-term ethanol consumption selectively impairs ganglioside pathway in rat brain publication-title: Alcohol.: Clin. Exp. Res. doi: 10.1111/j.1530-0277.1998.tb03902.x – volume: 83 start-page: 623 year: 2001 ident: 10.1016/j.bbagen.2006.09.023_bib40 article-title: N-Glycolylneuraminic acid in human tumours publication-title: Biochimie doi: 10.1016/S0300-9084(01)01303-7 |
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| SubjectTerms | Animals Biochemical engineering Brain - metabolism Cell Membrane - metabolism Flow Cytometry Genetic Engineering Hexosamines - metabolism Liver - metabolism Male Mice Mice, Inbred C57BL Muscle, Skeletal - metabolism Myocardium - metabolism N-Acetylneuraminic Acid - biosynthesis N-Acetylneuraminic Acid - blood N-Acetylneuraminic Acid - metabolism Neural cell adhesion molecule Organ Specificity Polysialic acid Sialic acid Subcellular Fractions - metabolism |
| Title | Engineering the sialic acid in organs of mice using N-propanoylmannosamine |
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