Variations at the H-strand replication origins of mitochondrial DNA and mitochondrial DNA content in the blood of type 2 diabetes patients

• Published in: Biochimica et biophysica acta Vol. 1787; no. 5; pp. 547 - 552
• Main Authors: Cormio, Antonella, Milella, Francesco, Marra, Maurizio, Pala, Maria, Lezza, Angela Maria Serena, Bonfigli, Anna Rita, Franceschi, Claudio, Cantatore, Palmiro, Gadaleta, Maria Nicola
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2009
• Subjects: Aged; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - genetics; DNA - blood; DNA - genetics; DNA - isolation & purification; DNA Primers; DNA Replication - genetics; DNA, Mitochondrial - blood; DNA, Mitochondrial - genetics; Female; Genetic Variation; Humans; Male; Middle Aged; Mitochondrial DNA content; Mitochondrial DNA D-loop sequence variation; Polymorphism, Single Nucleotide; Reference Values; Replication Origin - genetics; Transcription, Genetic; Type 2 diabetes; Type 2 diabetes; Mitochondrial DNA D-loop sequence variation; Mitochondrial DNA content

Mitochondrial DNA (mtDNA) sequence variation in the segment of the D-loop region encompassing the initiation sites for replication and transcription was analyzed in the blood of 277 Italian type 2 diabetes patients and 277 Italian healthy subjects. Compared with the Cambridge Reference Sequence, dia...