Analysis of small intestinal transit and colon arrival times of non-disintegrating tablets administered in the fasted state

• Published in: European journal of pharmaceutical sciences Vol. 75; pp. 131 - 141
• Main Authors: Pišlar, Mitja, Brelih, Hana, Mrhar, Aleš, Bogataj, Marija
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30.07.2015
• Subjects: Administration, Oral; Colon - physiology; Colon arrival; Fasting - physiology; Food-Drug Interactions; Gastric Emptying; Gastrointestinal Transit; Humans; Ileocecal junction residence; Intestine, Small - physiology; Non-disintegrating tablet; Post-dose meal intake; Small intestinal transit; Tablets - pharmacokinetics; Small intestinal transit; Ileocecal junction residence; Gastric emptying; Post-dose meal intake; Non-disintegrating tablet; Colon arrival

[Display omitted] In this study individual data on tablet gastrointestinal transit times (i.e. gastric emptying, small intestinal transit, ileocecal junction residence, and colon arrival times) were obtained from literature in order to present and analyze their distributions and relationships. The i...