A first-in-man study of [18F] FEDAC: a novel PET tracer for the 18-kDa translocator protein

• Published in: Annals of nuclear medicine Vol. 38; no. 4; pp. 264 - 271
• Main Authors: Tamura, Kentaro, Nishii, Ryuichi, Tani, Kotaro, Hashimoto, Hiroki, Kawamura, Kazunori, Zhang, Ming-Rong, Maeda, Takamasa, Yamazaki, Kana, Higashi, Tatsuya, Jinzaki, Masahiro
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.04.2024; Springer Nature B.V
• Subjects: Accumulation; Biliary tract; Biodistribution; Carrier Proteins - metabolism; Computed tomography; Fluorine isotopes; Gastrointestinal system; Gastrointestinal tract; Humans; Image quality; Imaging; Inflammation; Liver; Medicine; Medicine & Public Health; Neurodegenerative diseases; Neuroimaging; Nuclear Medicine; Original; Original Article; Positron emission; Positron emission tomography; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography - methods; Proteins; Radiation effects; Radioactive tracers; Radiology; Radiometry; Radiopharmaceuticals; Receptors, GABA - metabolism; Tissue Distribution; Urinary bladder; Translocator Protein; Radiation Dosimetry; TSPO; Normal healthy volunteers; Positron emission tomography; Biodistribution; IDAC

Purpose N-benzyl-N-methyl-2-[7, 8-dihydro-7-(2-[ 18 F] fluoroethyl) -8-oxo-2-phenyl-9H-purin-9-yl] acetamide ([ 18 F] FEDAC) is a novel positron emission tomography (PET) tracer that targets the translocator protein (TSPO; 18 kDa) in the mitochondrial outer membrane, which is known to be upregulated...