Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence

• Published in: Nature nanotechnology Vol. 12; no. 7; pp. 692 - 700
• Main Authors: Xue, Jingwei, Zhao, Zekai, Zhang, Lei, Xue, Lingjing, Shen, Shiyang, Wen, Yajing, Wei, Zhuoyuan, Wang, Lu, Kong, Lingyi, Sun, Hongbin, Ping, Qineng, Mo, Ran, Zhang, Can
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2017; Nature Publishing Group
• Subjects: 639/925/352/152; 639/925/352/2733; Brain; Brain cancer; Brain tumors; Drug delivery; Drug delivery systems; Glioma; Glioma cells; Immune system; Immunosuppressive agents; Inflammation; Leukocytes (neutrophilic); Liposomes; Materials Science; Nanotechnology; Nanotechnology and Microengineering; Paclitaxel; Regrowth; Survival; Tumors

Cell-mediated drug-delivery systems have received considerable attention for their enhanced therapeutic specificity and efficacy in cancer treatment. Neutrophils (NEs), the most abundant type of immune cells, are known to penetrate inflamed brain tumours. Here we show that NEs carrying liposomes tha...