Hopf Bifurcation on a Cancer Therapy Model by Oncolytic Virus Involving the Malignancy Effect and Therapeutic Efficacy

• Published in: International journal of mathematics and mathematical sciences Vol. 2020; no. 2020; pp. 1 - 8
• Main Authors: Norhidayah, S., Risdayati, S., Aryati, Lina, Adi-Kusumo, F.
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; Hindawi Limited; Wiley
• Subjects: Cancer; Cancer therapies; Deactivation; Hopf bifurcation; Immune system; Immunotherapy; Mathematical models; Mutation; Parameters; Predator-prey simulation; Therapy; Viruses

We introduce a mathematical model that shows the interaction dynamics between the uninfected and the infected cancer cell populations with oncolytic viruses for the benign and the malignant cancer cases. There are two important parameters in our model that represent the malignancy level of the cance...