Shortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging

• Published in: Blood Vol. 95; no. 9; pp. 2860 - 2868
• Main Authors: Fagnoni, Francesco F., Vescovini, Rosanna, Passeri, Giovanni, Bologna, Giovanni, Pedrazzoni, Mario, Lavagetto, Giampaolo, Casti, Amos, Franceschi, Claudio, Passeri, Mario, Sansoni, Paolo
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 01.05.2000; The Americain Society of Hematology
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Aging - immunology; Antigens, CD - blood; Biological and medical sciences; CD4 Lymphocyte Count; CD8-Positive T-Lymphocytes - immunology; General aspects; Humans; Immunologic Deficiency Syndromes - blood; Immunologic Deficiency Syndromes - epidemiology; Immunologic Deficiency Syndromes - immunology; Immunopathology; L-Selectin - analysis; Leukocyte Common Antigens - analysis; Lymphocyte Activation; Lymphocyte Count; Medical sciences; Middle Aged; Regression Analysis; T-Lymphocytes - immunology; Human; Immunopathology; Senescence; Middle age; Healthy subject; Ageing; Cellular immunity; Immunity; Immune deficiency; Immunosuppression; Etiology; Immunological investigation; Young adult; T-Lymphocyte; Suppressive cell; Physiology; Elderly; Age

Clinical observations indicate that elderly people are prone to severe, often lethal infectious diseases induced by novel pathogens. Since the ability to mount primary immune responses relies on the availability of naive T cells, the circulating naive T-cell reservoir was evaluated throughout the hu...