Alternative splicing: A new drug target of the post-genome era

• Published in: Biochimica et biophysica acta Vol. 1754; no. 1; pp. 324 - 331
• Main Author: Hagiwara, Masatoshi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30.12.2005
• Subjects: Alternative Splicing; Animals; Clk; Drug Delivery Systems; Enzyme Inhibitors - pharmacology; Humans; Phosphorylation; RNA Precursors - metabolism; RNA, Messenger - metabolism; Signal Transduction - drug effects; SR protein; SRPK; TG003; NSSR; Alternative splicing; Clk; PRP4; CaMKIV; ESE; PI 3-kinase; ISE; CaRRE; SR; TG003; hnRNP; ESS; ISS; PKC; PP2A; PP1; SAM68; STAR; DRB; SMN; ICH-1; SR protein; SRPK; STREX; ERK

Alternative splicing allows for the creation of multiple distinct mRNA transcripts from a given gene in a multicellular organism. Pre-mRNA splicing is catalyzed by a multi-molecular complex, including serine/arginine-rich (SR) proteins, which are highly phosphorylated in living cells, and thought to...