Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo

• Published in: Biochimica et biophysica acta Vol. 1770; no. 4; pp. 578 - 584
• Main Authors: Ochiai, Takashi, Shimeno, Hiroshi, Mishima, Ken-ichi, Iwasaki, Katsunori, Fujiwara, Michihiro, Tanaka, Hiroyuki, Shoyama, Yukihiro, Toda, Akihisa, Eyanagi, Reiko, Soeda, Shinji
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2007
• Subjects: Animals; Antioxidants - chemistry; Antioxidants - isolation & purification; Antioxidants - pharmacology; Brain Infarction - etiology; Brain Infarction - pathology; Brain Infarction - prevention & control; Carotenoids - chemistry; Carotenoids - isolation & purification; Carotenoids - pharmacology; Caspase 3 - metabolism; Cell Hypoxia; Cell Survival - drug effects; Cerebral ischemia; Crocetin glycosides; Crocus - chemistry; Cyclohexenes - pharmacology; Disease Models, Animal; Glucosides - pharmacology; Glutamate-Cysteine Ligase - metabolism; Glutathione; Glutathione - biosynthesis; Hypoxia; Infarction, Middle Cerebral Artery - complications; Lipid Peroxidation - drug effects; Male; Membrane Lipids - metabolism; Mice; Molecular Structure; Neuronal cell death; Neurons - drug effects; Neuroprotective Agents - chemistry; Neuroprotective Agents - isolation & purification; Neuroprotective Agents - pharmacology; PC12 Cells; Rats; Saffron; Structure-Activity Relationship; Terpenes - pharmacology; Time Factors; Hypoxia; Cerebral ischemia; Saffron; Crocetin glycosides; Neuronal cell death; Glutathione

Crocus sativus L. (saffron) has been used as a spice for flavoring and coloring food preparations, and in Chinese traditional medicine as an anodyne or tranquilizer. Our previous study demonstrated that crocin, a carotenoid pigment of saffron, can suppress the serum deprivation-induced death of PC12...