Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo - Ochiai, Takashi; Shimeno, Hiroshi; Mishima, Ken-ichi; Iwasaki, Katsunori; Fujiwara, Michihiro; Tanaka, Hiroyuki; Shoyama, Yukihiro; Toda, Akihisa; Eyanagi, Reiko; Soeda, Shinji (Biochimica et biophysica acta, 2007)
Keywords: Animals; Antioxidants - chemistry; Antioxidants - isolation & purification; Antioxidants - pharmacology; Brain Infarction - etiology; Brain Infarction - pathology; Brain Infarction - prevention & control; Carotenoids - chemistry; Carotenoids - isolation & purification; Carotenoids - pharmacology; Caspase 3 - metabolism; Cell Hypoxia; Cell Survival - drug effects; Cerebral ischemia; Crocetin glycosides; Crocus - chemistry; Cyclohexenes - pharmacology; Disease Models, Animal; Glucosides - pharmacology; Glutamate-Cysteine Ligase - metabolism; Glutathione; Glutathione - biosynthesis; Hypoxia; Infarction, Middle Cerebral Artery - complications; Lipid Peroxidation - drug effects; Male; Membrane Lipids - metabolism; Mice; Molecular Structure; Neuronal cell death; Neurons - drug effects; Neuroprotective Agents - chemistry; Neuroprotective Agents - isolation & purification; Neuroprotective Agents - pharmacology; PC12 Cells; Rats; Saffron; Structure-Activity Relationship; Terpenes - pharmacology; Time Factors; Hypoxia; Cerebral ischemia; Saffron; Crocetin glycosides; Neuronal cell death; Glutathione