Newly identified single-nucleotide polymorphism associated with the transition from nonalcoholic fatty liver disease to liver fibrosis: results from a nested case-control study in the UK biobank

• Published in: Annals of medicine (Helsinki) Vol. 57; no. 1; p. 2458201
• Main Authors: Ling, Yitong, Yang, Yu Xuan, Chen, Yan Chun, Wang, Jing Hao, Feng, Dong Ge, Xiang, Shi Jian, Zhang, Xiaoyu, Lyu, Jun, Li, Sha Sha
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.12.2025; Taylor & Francis Group
• Subjects: Adult; Aged; Biological Specimen Banks; Case-Control Studies; Cell Line; Collagen Type I, alpha 1 Chain; Disease Progression; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Hepatic Stellate Cells - metabolism; Hepatology; Humans; liver cirrhosis; Liver Cirrhosis - genetics; Liver Cirrhosis - pathology; Male; Middle Aged; Non-alcoholic Fatty Liver Disease - complications; Non-alcoholic Fatty Liver Disease - genetics; Non-alcoholic Fatty Liver Disease - pathology; nonalcoholic fatty liver disease; Oxidative Stress - genetics; Polymorphism, Single Nucleotide; SAMM50-rs2073080; Single-nucleotide polymorphism; UK Biobank; United Kingdom - epidemiology; United Kingdom; SAMM50-rs2073080; nonalcoholic fatty liver disease; Single-nucleotide polymorphism; liver cirrhosis

Genetic factors may have a significant influence on the likelihood of liver fibrosis in individuals with nonalcoholic fatty liver disease (NAFLD). The present study was conducted to explore how single-nucleotide polymorphism (SNP) impacts the development of fibrosis in those suffering from NAFLD. Ut...