Flavonols and flavones as BACE-1 inhibitors: Structure–activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features - Shimmyo, Yoshiari; Kihara, Takeshi; Akaike, Akinori; Niidome, Tetsuhiro; Sugimoto, Hachiro (Biochimica et biophysica acta, 2008)
Keywords: Alzheimer Disease - drug therapy; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Amyloid Precursor Protein Secretases - antagonists & inhibitors; Amyloid Precursor Protein Secretases - chemistry; Amyloid Precursor Protein Secretases - metabolism; Animals; Apigenin - chemistry; Apigenin - pharmacology; Aspartic Acid Endopeptidases - antagonists & inhibitors; Aspartic Acid Endopeptidases - chemistry; Aspartic Acid Endopeptidases - metabolism; BACE-1; Catalytic Domain; Cell Survival - drug effects; Cerebral Cortex - cytology; Flavones - chemistry; Flavones - pharmacology; Flavonoid; Flavonoids - chemistry; Flavonoids - pharmacology; Flavonols - chemistry; Flavonols - pharmacology; Humans; Hydrogen Bonding; Kaempferols - chemistry; Kaempferols - pharmacology; Models, Molecular; Molecular Structure; Neurons - drug effects; Neurons - enzymology; Neurons - metabolism; Pharmacophore; Primary neuron; Protease Inhibitors - chemistry; Protease Inhibitors - pharmacology; Quercetin - chemistry; Quercetin - pharmacology; Rats; Structure-Activity Relationship; Aβ; Primary neuron; Flavonoid; Alzheimer's disease; Pharmacophore; BACE-1