Role of cGMP in hydrogen sulfide signaling

• Published in: Nitric oxide Vol. 46; pp. 7 - 13
• Main Authors: Bibli, Sofia-Iris, Yang, Guangdong, Zhou, Zongmin, Wang, Rui, Topouzis, Stavros, Papapetropoulos, Andreas
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 30.04.2015
• Subjects: Angiogenesis; Animals; cGMP; Cyclic GMP - chemistry; Cyclic GMP - metabolism; Humans; Hydrogen sulfide; Hydrogen Sulfide - chemistry; Hydrogen Sulfide - metabolism; Mice; PKG; Relaxation; Signal Transduction; Hydrogen sulfide; Relaxation; Angiogenesis; cGMP; PKG

•H2S donors and endogenous H2S increase cGMP.•This is achieved by PDE inhibition, eNOS activation or increased NO bioavailability.•H2S is a non-selective PDE inhibitor.•Rate of H2S release determines the concentration of donor needed to increase cGMP.•Donors with faster release rates are more likely...