Role of the Autism Risk Gene Shank3 in the Development of Atherosclerosis: Insights from Big Data and Mechanistic Analyses

• Published in: Cells (Basel, Switzerland) Vol. 12; no. 21; p. 2546
• Main Authors: Chang, Hsiu-Wen, Hsu, Ming-Jen, Chien, Li-Nien, Chi, Nai-Fang, Yu, Meng-Chieh, Chen, Hsiu-Chen, Lin, Yuan-Feng, Hu, Chaur-Jong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.10.2023
• Subjects: Animals; Antibodies; Arteriosclerosis; Atherosclerosis; Atherosclerosis - genetics; Autism; autism spectrum disorder; Autism Spectrum Disorder - genetics; Autistic Disorder - genetics; Big Data; Biotechnology; Cardiovascular Diseases; cardiovascular disorder; Cell adhesion molecules; Cholesterol; Down-regulation; Fatty acids; Fatty-acid synthase; Gene expression; Gene set enrichment analysis; Genes; Heart attacks; Homeostasis; Humans; Hyperlipidemia; Hyperlipidemias; Inflammation; Ischemia; Kinases; lipid metabolism; Mice; Microfilament Proteins; Mutation; National health insurance; Nerve Tissue Proteins - genetics; Patients; Penicillin; Polymerase chain reaction; Population studies; Proteins; Shank3; Social interaction; Stroke; Tumor Necrosis Factor-alpha; Tumor necrosis factor-α; Vascular cell adhesion molecule 1; Young Adult; Young adults; United States > US; Taiwan; atherosclerosis; Shank3; autism spectrum disorder; inflammation; cardiovascular disorder; lipid metabolism

Increased medical attention is needed as the prevalence of autism spectrum disorder (ASD) rises. Both cardiovascular disorder (CVD) and hyperlipidemia are closely associated with adult ASD. Shank3 plays a key genetic role in ASD. We hypothesized that Shank3 contributes to CVD development in young ad...