The role of ubiquitin proteasomal system and autophagy-lysosome pathway in Alzheimer’s disease

• Published in: Reviews in the neurosciences Vol. 28; no. 8; pp. 861 - 868
• Main Authors: Zhang, Yuan, Chen, Xu, Zhao, Yanfang, Ponnusamy, Murugavel, Liu, Ying
• Format: Journal Article
• Language: English
• Published: Germany De Gruyter 27.11.2017
• Subjects: Alzheimer disease; autophagy-lysosomal pathway; tau; ubiquitin proteasomal system; β-amyloid; autophagy-lysosomal pathway; tau; ubiquitin proteasomal system; Alzheimer disease; β-amyloid

Alzheimer’s disease (AD) is the most common neurodegenerative disorder leading to dementia in the elderly population. AD is associated with the buildup of β-amyloid and tau, which aggregate into extracellular plaques and neurofibrillary tangles. Although the exact mechanism of pathological process o...