Positron emission tomography (PET) imaging of nicotine-induced dopamine release in squirrel monkeys using [18F]Fallypride

• Published in: Drug and alcohol dependence Vol. 179; pp. 254 - 259
• Main Authors: Naylor, Jennifer E., Hiranita, Takato, Matazel, Katelin S., Zhang, Xuan, Paule, Merle G., Goodwin, Amy K.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.10.2017; Elsevier Science Ltd
• Subjects: Animals; Benzamides; Body weight; Brain; Brain - diagnostic imaging; Brain - drug effects; Brain Mapping; Cerebellum; Corpus Striatum - metabolism; Dopamine; Dopamine D2 receptors; Dopamine D3 receptors; Dopamine receptors; Drug abuse; Emissions; Fallypride; Hostility; Imaging; Injection; Male; Mesolimbic system; Monkeys; Neostriatum; Neostriatum - metabolism; Neuroimaging; Nicotine; Nicotine - pharmacology; Pet; Positron emission; Positron emission tomography; Positron-Emission Tomography - methods; Primate; Primates; Pyrrolidines - chemistry; Pyrrolidines - pharmacology; Radioactivity; Receptors, Dopamine D2 - metabolism; Receptors, Dopamine D3 - metabolism; Release; Saimiri; Saline solutions; Substance abuse; Tobacco; Tomography; Uptake; Variance analysis; Primate; Dopamine; Imaging; Fallypride; Pet; Nicotine

•Study of the effects of nicotine on dopamine (DA) D2/D3 receptors in squirrel monkey brains.•Nicotine administration resulted in ligand uptake across brain regions.•Tobacco products containing nicotine may cause alterations to the DA system. Nicotine, the principal psychoactive tobacco constituent,...