Selective serotonin reuptake inhibitors provide significant lower re-hospitalization rates in patients recovering from acute coronary syndromes: evidence from a meta-analysis

• Published in: Journal of psychopharmacology (Oxford) Vol. 24; no. 12; p. 1785
• Main Authors: Mazza, Marianna, Lotrionte, Marzia, Biondi-Zoccai, Giuseppe, Abbate, Antonio, Sheiban, Imad, Romagnoli, Enrico
• Format: Journal Article
• Language: English
• Published: United States 01.12.2010
• Subjects: Acute Coronary Syndrome - complications; Acute Coronary Syndrome - physiopathology; Antidepressive Agents, Second-Generation - adverse effects; Antidepressive Agents, Second-Generation - pharmacology; Depressive Disorder - complications; Depressive Disorder - drug therapy; Hospitalization - statistics & numerical data; Humans; Prognosis; Randomized Controlled Trials as Topic; Serotonin Uptake Inhibitors - adverse effects; Serotonin Uptake Inhibitors - pharmacology; Time Factors; Treatment Outcome

Depression is an independent negative prognostic factor in patients with acute coronary syndromes (ACS), yet it is unclear if its treatment is beneficial after ACS. We sought to compare, through a meta-analytic process, antidepressant therapy with selective serotonin reuptake inhibitors (SSRIs) vers...