HTHQ (1- O-hexyl-2,3,5-trimethylhydroquinone), an anti-lipid-peroxidative compound: its chemical and biochemical characterizations

• Published in: Biochimica et biophysica acta Vol. 1425; no. 1; pp. 47 - 60
• Main Authors: Hino, Tadayuki, Kawanishi, Shinya, Yasui, Hiroyuki, Oka, Shigenori, Sakurai, Hiromu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 16.09.1998
• Subjects: 1- O-Hexyl-2,3,5-trimethylhydroquinone; Animals; Anti-lipid peroxidative compound; Anti-oxidative agent; Antioxidants - chemistry; Antioxidants - pharmacology; d, l-α-Tocopherol; Electron spin resonance; Electron Spin Resonance Spectroscopy; Free Radical Scavengers - chemistry; Free Radical Scavengers - pharmacology; Hydroquinones - chemistry; Hydroquinones - pharmacology; Hydroxyl Radical - metabolism; In Vitro Techniques; Lipid peroxidation; Lipid Peroxidation - drug effects; Liposomes; Micelles; Microsomes, Liver - drug effects; Microsomes, Liver - metabolism; Rats; Rats, Wistar; Reactive oxygen species; Reactive Oxygen Species - metabolism; Superoxides - metabolism; tert-Butylhydroperoxide - metabolism; 1- O-Hexyl-2,3,5-trimethylhydroquinone; d, l-α-Tocopherol; Reactive oxygen species; Electron spin resonance; Lipid peroxidation; Anti-lipid peroxidative compound; Anti-oxidative agent

Recently, it has become apparent that reactive oxygen species (ROS) play many important roles in biological systems. For example, relationships between many diseases, such as cancer, cardiac infarction and arteriosclerosis, and ROS have been found. It is also well known that anti-oxidative agents sc...