Analysis of the intramolecular 1,7-lactone of N-acetylneuraminic acid using HPLC–MS: relationship between detection and stability

• Published in: Glycoconjugate journal Vol. 40; no. 3; pp. 343 - 354
• Main Authors: La Rocca, Paolo, Lavota, Ivana, Piccoli, Marco, Cirillo, Federica, Ghiroldi, Andrea, Ciconte, Giuseppe, Pappone, Carlo, Allevi, Pietro, Rota, Paola, Anastasia, Luigi
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2023; Springer Nature B.V
• Subjects: Acids; Biochemistry; Biomedical and Life Sciences; Chromatography; Chromatography, High Pressure Liquid; High-performance liquid chromatography; Lability; Laboratories; Lactones; Life Sciences; Mass spectrometry; N-Acetylneuraminic Acid; NMR; Nuclear magnetic resonance; Pathology; Physiology; Scientific imaging; Sialic Acids - analysis; Signal transduction; Solvents; 1,7-lactone; γ-lactone; Sialic acids; HPLC–MS analysis; acetylneuraminic acid; N-acetylneuraminic acid

A subclass of the sialic acid family consists of intramolecular lactones that may function as key indicators of physiological and pathological states. However, the existence of these compounds in free form is highly improbable, since they are unlikely to exist in an aqueous solution due to their lab...