Graft–Host Interaction and Its Effect on Wound Repair Using Mouse Models

• Published in: International journal of molecular sciences Vol. 24; no. 22; p. 16277
• Main Authors: Garcia, Nicole, Rahman, Md Mostafizur, Arellano, Carlos Luis, Banakh, Ilia, Yung-Chih, Chen, Peter, Karlheinz, Cleland, Heather, Lo, Cheng Hean, Akbarzadeh, Shiva
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.11.2023
• Subjects: Analysis; Angiogenesis; Care and treatment; Chemokines; Collagen; Cytokines; Fibroblasts; IL-6; Inflammation; Insulin-like growth factors; myofibroblast; Plastic surgery; RNA; Scars; Scientific equipment and supplies industry; Skin; Skin & tissue grafts; skin grafting; TGF-β1; Transforming growth factors; Tumor necrosis factor-TNF; Vascular endothelial growth factor; Wound healing; wound repair; Wounds and injuries; Australia; United States

Autologous skin grafting has been commonly used in clinics for decades to close large wounds, yet the cellular and molecular interactions between the wound bed and the graft that mediates the wound repair are not fully understood. The aim of this study was to better understand the molecular changes...