Increasing age of multiple sclerosis onset from 1920 to 2022: a population-based study
Objective To study the age at onset of relapsing–remitting multiple sclerosis (RRMS) during the past century. Methods This is a population-based cohort study of persons diagnosed with RRMS in Hordaland, Møre, and Romsdal counties, Western Norway, from 1920 to 2022. Individual patient data were avail...
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Published in | Journal of neurology Vol. 271; no. 4; pp. 1610 - 1617 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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Berlin/Heidelberg
Springer Berlin Heidelberg
01.04.2024
Springer Nature B.V |
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Abstract | Objective
To study the age at onset of relapsing–remitting multiple sclerosis (RRMS) during the past century.
Methods
This is a population-based cohort study of persons diagnosed with RRMS in Hordaland, Møre, and Romsdal counties, Western Norway, from 1920 to 2022. Individual patient data were available and assessed from previously conducted prevalence and incidence studies in addition to hospital records up until October 31, 2022. Participants were categorized according to onset period and analyzed for temporal trends in age at onset, time from onset to diagnosis, and distribution of onset over time.
Results
We identified 3364 persons with confirmed RRMS. The mean age at onset significantly increased (
p
< 0.001) throughout the study period, despite a decrease in time from symptom onset to diagnosis (
p
< 0.001). The proportion of persons with MS onset after 50 years of age increased from 2.6% before 1970 to 11.9% after 2010
.
We also found a trend toward a bimodal distribution of age at onset that peaked at around 30 years and 40–45 years of age in the latest period.
Conclusion
Age at onset of MS significantly increased throughout the study period. This was mainly due to an increasing number of persons with MS, predominantly female, experiencing onset after 40–45 years of age. This bimodal distribution could indicate different susceptibility periods of MS or changes in exposure to risk factors during the observation period
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AbstractList | ObjectiveTo study the age at onset of relapsing–remitting multiple sclerosis (RRMS) during the past century.MethodsThis is a population-based cohort study of persons diagnosed with RRMS in Hordaland, Møre, and Romsdal counties, Western Norway, from 1920 to 2022. Individual patient data were available and assessed from previously conducted prevalence and incidence studies in addition to hospital records up until October 31, 2022. Participants were categorized according to onset period and analyzed for temporal trends in age at onset, time from onset to diagnosis, and distribution of onset over time.ResultsWe identified 3364 persons with confirmed RRMS. The mean age at onset significantly increased (p < 0.001) throughout the study period, despite a decrease in time from symptom onset to diagnosis (p < 0.001). The proportion of persons with MS onset after 50 years of age increased from 2.6% before 1970 to 11.9% after 2010. We also found a trend toward a bimodal distribution of age at onset that peaked at around 30 years and 40–45 years of age in the latest period.ConclusionAge at onset of MS significantly increased throughout the study period. This was mainly due to an increasing number of persons with MS, predominantly female, experiencing onset after 40–45 years of age. This bimodal distribution could indicate different susceptibility periods of MS or changes in exposure to risk factors during the observation period. Objective To study the age at onset of relapsing–remitting multiple sclerosis (RRMS) during the past century. Methods This is a population-based cohort study of persons diagnosed with RRMS in Hordaland, Møre, and Romsdal counties, Western Norway, from 1920 to 2022. Individual patient data were available and assessed from previously conducted prevalence and incidence studies in addition to hospital records up until October 31, 2022. Participants were categorized according to onset period and analyzed for temporal trends in age at onset, time from onset to diagnosis, and distribution of onset over time. Results We identified 3364 persons with confirmed RRMS. The mean age at onset significantly increased ( p < 0.001) throughout the study period, despite a decrease in time from symptom onset to diagnosis ( p < 0.001). The proportion of persons with MS onset after 50 years of age increased from 2.6% before 1970 to 11.9% after 2010 . We also found a trend toward a bimodal distribution of age at onset that peaked at around 30 years and 40–45 years of age in the latest period. Conclusion Age at onset of MS significantly increased throughout the study period. This was mainly due to an increasing number of persons with MS, predominantly female, experiencing onset after 40–45 years of age. This bimodal distribution could indicate different susceptibility periods of MS or changes in exposure to risk factors during the observation period . Abstract Objective To study the age at onset of relapsing–remitting multiple sclerosis (RRMS) during the past century. Methods This is a population-based cohort study of persons diagnosed with RRMS in Hordaland, Møre, and Romsdal counties, Western Norway, from 1920 to 2022. Individual patient data were available and assessed from previously conducted prevalence and incidence studies in addition to hospital records up until October 31, 2022. Participants were categorized according to onset period and analyzed for temporal trends in age at onset, time from onset to diagnosis, and distribution of onset over time. Results We identified 3364 persons with confirmed RRMS. The mean age at onset significantly increased ( p < 0.001) throughout the study period, despite a decrease in time from symptom onset to diagnosis ( p < 0.001). The proportion of persons with MS onset after 50 years of age increased from 2.6% before 1970 to 11.9% after 2010 . We also found a trend toward a bimodal distribution of age at onset that peaked at around 30 years and 40–45 years of age in the latest period. Conclusion Age at onset of MS significantly increased throughout the study period. This was mainly due to an increasing number of persons with MS, predominantly female, experiencing onset after 40–45 years of age. This bimodal distribution could indicate different susceptibility periods of MS or changes in exposure to risk factors during the observation period . To study the age at onset of relapsing-remitting multiple sclerosis (RRMS) during the past century. This is a population-based cohort study of persons diagnosed with RRMS in Hordaland, Møre, and Romsdal counties, Western Norway, from 1920 to 2022. Individual patient data were available and assessed from previously conducted prevalence and incidence studies in addition to hospital records up until October 31, 2022. Participants were categorized according to onset period and analyzed for temporal trends in age at onset, time from onset to diagnosis, and distribution of onset over time. We identified 3364 persons with confirmed RRMS. The mean age at onset significantly increased (p < 0.001) throughout the study period, despite a decrease in time from symptom onset to diagnosis (p < 0.001). The proportion of persons with MS onset after 50 years of age increased from 2.6% before 1970 to 11.9% after 2010. We also found a trend toward a bimodal distribution of age at onset that peaked at around 30 years and 40-45 years of age in the latest period. Age at onset of MS significantly increased throughout the study period. This was mainly due to an increasing number of persons with MS, predominantly female, experiencing onset after 40-45 years of age. This bimodal distribution could indicate different susceptibility periods of MS or changes in exposure to risk factors during the observation period. |
Author | Myhr, K. M. Habbestad, A. Grytten, N. Wergeland, S. Willumsen, J. S. Midgard, R. Torkildsen, Ø. Aarseth, J. H. |
Author_xml | – sequence: 1 givenname: A. surname: Habbestad fullname: Habbestad, A. organization: Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Department of Clinical Medicine, University of Bergen – sequence: 2 givenname: J. S. surname: Willumsen fullname: Willumsen, J. S. organization: Department of Neurology, Molde Hospital, Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology – sequence: 3 givenname: J. H. surname: Aarseth fullname: Aarseth, J. H. organization: Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Norwegian Multiple Sclerosis Registry and Biobank, Haukeland University Hospital – sequence: 4 givenname: N. surname: Grytten fullname: Grytten, N. organization: Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Department of Clinical Medicine, University of Bergen – sequence: 5 givenname: R. surname: Midgard fullname: Midgard, R. organization: Department of Neurology, Molde Hospital – sequence: 6 givenname: S. surname: Wergeland fullname: Wergeland, S. organization: Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Department of Clinical Medicine, University of Bergen, Norwegian Multiple Sclerosis Registry and Biobank, Haukeland University Hospital – sequence: 7 givenname: K. M. surname: Myhr fullname: Myhr, K. M. organization: Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Department of Clinical Medicine, University of Bergen – sequence: 8 givenname: Ø. surname: Torkildsen fullname: Torkildsen, Ø. email: oivind.torkildsen@gmail.com organization: Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Department of Clinical Medicine, University of Bergen |
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Keywords | Multiple sclerosis Sex-difference Prevalence Cohort Age |
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Snippet | Objective
To study the age at onset of relapsing–remitting multiple sclerosis (RRMS) during the past century.
Methods
This is a population-based cohort study... To study the age at onset of relapsing-remitting multiple sclerosis (RRMS) during the past century. This is a population-based cohort study of persons... Abstract Objective To study the age at onset of relapsing–remitting multiple sclerosis (RRMS) during the past century. Methods This is a population-based... ObjectiveTo study the age at onset of relapsing–remitting multiple sclerosis (RRMS) during the past century.MethodsThis is a population-based cohort study of... OBJECTIVETo study the age at onset of relapsing-remitting multiple sclerosis (RRMS) during the past century.METHODSThis is a population-based cohort study of... |
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SubjectTerms | Age Age composition Age of Onset Cohort Studies Diagnosis Female Humans Male Medicine Medicine & Public Health Multiple sclerosis Multiple Sclerosis - epidemiology Multiple Sclerosis, Relapsing-Remitting - epidemiology Neurology Neuroradiology Neurosciences Norway - epidemiology Original Communication Population studies Prevalence Risk factors |
Title | Increasing age of multiple sclerosis onset from 1920 to 2022: a population-based study |
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