Prognostic implications of CD9 in childhood acute lymphoblastic leukemia: insights from a nationwide multicenter study in China

• Published in: Leukemia Vol. 38; no. 2; pp. 250 - 257
• Main Authors: Leung, Kam Tong, Cai, Jiaoyang, Liu, Yu, Chan, Kathy Yuen Yee, Shao, Jingbo, Yang, Hui, Hu, Qun, Xue, Yao, Wu, Xuedong, Guo, Xia, Zhai, Xiaowen, Wang, Ningling, Li, Xue, Tian, Xin, Li, Zheng, Xue, Ning, Guo, Yuxia, Wang, Lingzhen, Zou, Yao, Xiao, Peifang, He, Yingyi, Jin, Runming, Tang, Jingyan, Yang, Jun J., Shen, Shuhong, Pui, Ching-Hon, Li, Chi Kong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2024; Nature Publishing Group
• Subjects: 13; 13/31; 692/699/1541/1990/283/2125; 692/700/1750; Acute lymphoblastic leukemia; Cancer Research; CD9 antigen; Chemotherapy; Child; Childhood; Children; China; Critical Care Medicine; Cytogenetics; Diagnostic systems; Flow cytometry; Hematology; Humans; Intensive; Internal Medicine; Leukemia; Lymphocytes T; Medical prognosis; Medicine; Medicine & Public Health; Neoplasm, Residual - diagnosis; Oncology; Parameters; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy; Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission; Risk levels; Tetraspanin 29; China
• ISSN: 0887-6924; 1476-5551; 1476-5551
• DOI: 10.1038/s41375-023-02089-3

The outcomes of children with acute lymphoblastic leukemia (ALL) have been incrementally improved with risk-directed chemotherapy but therapy responses remain heterogeneous. Parameters with added prognostic values are warranted to refine the current risk stratification system and inform appropriate...