Intratumoral cisplatin/epinephrine-injectable gel as a palliative treatment for accessible solid tumors: a multicenter pilot study

• Published in: Otolaryngology-head and neck surgery Vol. 118; no. 4; p. 496
• Main Authors: Burris, 3rd, H A, Vogel, C L, Castro, D, Mishra, L, Schwarz, M, Spencer, S, Oakes, D D, Korey, A, Orenberg, E K
• Format: Journal Article
• Language: English
• Published: England 01.04.1998
• Subjects: Adenocarcinoma - drug therapy; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell - drug therapy; Cisplatin - administration & dosage; Cisplatin - adverse effects; Dose-Response Relationship, Drug; Epinephrine - administration & dosage; Epinephrine - adverse effects; Female; Gels; Head and Neck Neoplasms - drug therapy; Humans; Injections, Intralesional; Male; Melanoma - drug therapy; Middle Aged; Otorhinolaryngologic Neoplasms - drug therapy; Palliative Care; Pilot Projects; Skin Neoplasms - drug therapy; Soft Tissue Neoplasms - drug therapy; Treatment Outcome

Intratumoral injections of cisplatin/epinephrine-injectable gel were administered weekly for 4 weeks in 45 patients with malignant tumors of various histologic types. Tumors were located on the skin and subcutaneous tissue primarily of the head, neck, and trunk, and on the tongue, oral pharynx, and...