Optimal design of cluster randomized crossover trials with a continuous outcome: Optimal number of time periods and treatment switches under a fixed number of clusters or fixed budget

• Published in: Behavior research methods Vol. 56; no. 8; pp. 8820 - 8830
• Main Author: Moerbeek, Mirjam
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2024; Springer Nature B.V
• Subjects: Behavioral Science and Psychology; Budgets - methods; Cluster Analysis; Cognitive Psychology; Cross-Over Studies; Cross-Sectional Studies; Design optimization; Humans; Original Manuscript; Psychology; Randomized Controlled Trials as Topic - economics; Randomized Controlled Trials as Topic - methods; Research Design; Time Factors; Crossover design; Treatment switches; Relative efficiency; Cluster randomized trial; Budgetary constraint; Optimal design

In the cluster randomized crossover trial, a sequence of treatment conditions, rather than just one treatment condition, is assigned to each cluster. This contribution studies the optimal number of time periods in studies with a treatment switch at the end of each time period, and the optimal number...