Effects of food and ethnicity on the pharmacokinetics of venadaparib, a next-generation PARP inhibitor, in healthy Korean, Caucasian, and Chinese male subjects

• Published in: Investigational new drugs Vol. 42; no. 1; pp. 80 - 88
• Main Authors: Kim, Hyun Chul, Yang, Eunsol, Lee, Soyoung, Oh, Jaeseong, Lee, Myongjae, Lee, ChaeEun, Ha, Kyoung Soo, Lee, Won Sik, Jang, In-Jin, Yu, Kyung-Sang
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2024; Springer Nature B.V
• Subjects: Dosage; Ethnicity; Food; Gastric cancer; Inhibitors; Labels; Males; Medicine; Medicine & Public Health; Minority & ethnic groups; Oncology; Oral administration; Pharmacokinetics; Pharmacology/Toxicology; Poly(ADP-ribose); Poly(ADP-ribose) polymerase; Ribose; Statistical analysis; Targeted cancer therapy; Time measurement; White people; Ethnic effect; Food effect; Pharmacokinetics; PARP inhibitor; Venadaparib

Aim Venadaparib is a next-generation poly(ADP-ribose) polymerase inhibitor under development for treating gastric cancer. This study aimed to evaluate the effects of food and ethnicity on the pharmacokinetics (PKs) and safety of venadaparib after a single oral administration in healthy Korean, Cauca...