SQST-1/p62-regulated SKN-1/Nrf mediates a phagocytic stress response via transcriptional activation of lyst-1/LYST

• Published in: PLoS genetics Vol. 21; no. 5; p. e1011696
• Main Authors: Elkhalil, Aladin, Whited, Alec, Ghose, Piya
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.05.2025; Public Library of Science (PLoS)
• Subjects: Animals; Biology and Life Sciences; Caenorhabditis elegans - genetics; Caenorhabditis elegans Proteins - genetics; Caenorhabditis elegans Proteins - metabolism; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Medicine and Health Sciences; Phagocytosis - genetics; Physical Sciences; Research and Analysis Methods; Sequestosome-1 Protein - genetics; Sequestosome-1 Protein - metabolism; Stress, Physiological - genetics; Transcription Factors - genetics; Transcription Factors - metabolism; Transcriptional Activation - genetics

Cells may be intrinsically fated to die to sculpt tissues during development or to maintain homeostasis. Cells can also die in response to various stressors, injury or pathological conditions. Additionally, cells of the metazoan body are often highly specialized with distinct domains that differ bot...