Diagnosis and Molecular Analysis on Imported Plasmodium ovale curtisi and P. ovale wallikeri Malaria Cases from West and South Africa during 2013-2016

• Published in: Korean journal of parasitology Vol. 58; no. 1; pp. 61 - 65
• Main Authors: Shin, Hyun-Il, Ku, Bora, Kim, Yu Jung, Kim, Tae Yun, Cho, Shin-Hyeong, Lee, Sang-Eun
• Format: Journal Article
• Language: English
• Published: Korea (South) 대한기생충학열대의학회 01.02.2020; The Korean Society for Parasitology and Tropical Medicine
• Subjects: Brief Communication; imported case; Plasmodium ovale; malaria; molecular analysis
• DOI: 10.3347/kjp.2020.58.1.61
• ISSN: 0023-4001; 1738-0006

Majority of the imported malaria cases in Korea is attributed to Plasmodium falciparum and P. vivax infections, whereas P. malariae and P. ovale infections are very rare. Falciparum and ovale malaria are mostly imported from Africa, while most of the vivax malaria cases are imported from Southeast Asia. Here, we report 6 Korean imported ovale malaria cases (4 males and 2 females) who had visited in Africa during 2013-2016. These subjects were diagnosed with P. ovale based on microscopic findings, Plasmodium species-specific nested-PCR, and phylogenetic clade using 18S rRNA gene sequences. We identified 2 P. ovale subtypes, 1 P. ovale curtisi (classic type) and 5 P. ovale wallikeri (variant type). All patients were treated with chloroquine and primaquine, and no relapse or recrudescence was reported for 1 year after treatment. With increase of travelers to the countries where existing Plasmodium species, the risk of Plasmodium infection is also increasing. Molecular monitoring for imported malaria parasites should be rigorously and continuously performed to enable diagnosis and certification of Plasmodium spp.